中医药治疗卵巢早衰表观遗传学调控研究进展  

Research progress of traditional Chinese medicine in the treatment of premature ovarian failure based on epigenetic regulation

作　　者：麦哲芬 黄曼秀 刘莹 揭慧敏 韩霞 MAI Zhefen;HUANG Manxiu;LIU Ying;JIE Huimin;HAN Xia(Department of Gynecology,Shenzhen Hospital of Guangzhou University of Chinese Medicine(Futian)the Sixth Clinical School of Guangzhou University of Chinese Medicine,Guangdong Province,Shenzhen 518034,China)

机构地区：[1]广州中医药大学深圳医院(福田)、广州中医药大学第六临床医学院妇科,广东深圳518034

出　　处：《中国医药导报》2024年第24期74-76,81,共4页China Medical Herald

基　　金：深圳市科技计划项目(JCYJ20210319124337003、JCYJ2023080720506014)。

摘　　要：表观遗传学研究DNA序列不变情况下的遗传表型变化,具有个体差异性、时空特异性及动态性,与中医整体观念和辨证论治思想相似。近年来,卵巢早衰(POF)发病率逐年升高且呈低龄化趋势,其机制复杂,表观遗传学变化可能是关键因素。本文综述中医药在POF治疗中的作用,并结合表观遗传学前沿研究,探讨其关键角色,为POF的理论研究和临床治疗提供新思路。Epigenetics studies the genetic phenotype changes under the condition of unchanged DNA sequences,which have individual differences,spatiotemporal specificity and dynamism,similar to holistic concept and dialectical treatment ideas of traditional Chinese medicine.In recent years,the incidence rate of premature ovarian failure(POF)has been increasing year by year and showing a trend of younger age.Its mechanism is complex,and epigenetic changes may be the key factor.This article reviews the role of traditional Chinese medicine in the treatment of POF and explores its key role in combination with previous research on epigenetics,providing new ideas for theoretical research and clinical treatment of POF.

关 键 词：卵巢早衰 表观遗传学 中医药 研究进展 

分 类 号：R271.9[医药卫生—中西医结合]