Application prospects of urine-derived stem cells in neurological and musculoskeletal diseases  

作　　者：Hui-Si Yang Yue-Xiang Zheng Xue Bai Xiu-Ying He Ting-Hua Wang 

机构地区：[1]Department of Neurology and National Traditional Chinese Medicine Clinical Research Base,The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China [2]Department of Anesthesiology,Institute of Neurological Disease,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [3]Department of Anesthesiology,Institute of Neurological Disease,Translational Neuroscience Center,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Orthopedics》2024年第10期918-931,共14页世界骨科杂志（英文）

基　　金：Supported by the Key Research and Development Program of Sichuan Science and Technology Agency,No.2020YFS0043;Natural Science Foundation of Sichuan Province of China,No.2023NSFSC1567;Sichuan University Innovation Research Project,No.2023SCUH0033;Innovation Team at the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,No.2022-CXTD-05.

摘　　要：Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional differentiation.Moreover,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived induced pluripotent stem cells(UiPSCs)]through transcription factors,such as octamer binding transcription factor 4,sex determining region Y-box 2,kruppel-like factor 4,myelocytomatosis oncogene,and Nanog homeobox and protein lin-28,in which the first four are known as Yamanaka factors.Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic,myogenic,and osteogenic differentiation,indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases.Therefore,we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review,which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs.

关 键 词：Urine-derived stem cells Urine-derived induced pluripotent stem cells Neurological diseases Musculoskeletal diseases Treatment prospect 

分 类 号：R658[医药卫生—外科学]