Prolonged course of Paxlovid administration in a centenarian with COVID-19:A case report  

作　　者：Yi-Xue Zhang Juan Tang Dan Zhu Chun-Yan Wu Mei-Lan Liang Yuan-Tao Huang 

机构地区：[1]Department of Healthcare,Haikou Affiliated Hospital of Central South University Xiangya School of Medicine,Haikou 570208,Hainan Province,China [2]Department of Healthcare,Hainan Chengmei Hospital,Haikou 570000,Hainan Province,China

出　　处：《World Journal of Radiology》2024年第9期489-496,共8页世界放射学杂志（英文）

摘　　要：BACKGROUND According to the population statistics in 2023,there were 110000 people aged over 100 years in China,and the experience of using Paxlovid(nirmatrelvir/ritonavir)for centenarians is particularly valuable.This article reports our experience of using Paxlovid in a centenarian with the novel coronavirus disease 2019(COVID-19)infection.CASE SUMMARY A 103-year-old female with mild COVID-19 and renal insufficiency was given sufficient Paxlovid for 2 days and a half dose for 3 days.During treatment,the patient was complicated with lung infection and heart failure,and nucleic acid remained positive.After expert consultation,a full dose of Paxlovid was given again on the 9th day of admission for 2 days and a half dose for 3 days.Meanwhile,anti-heart failure and antibiotics were administered;the heart failure and pulmonary infection were improved.Finally,on the 33^(th) day of admission,nucleic acid turned negative,body temperature returned to normal,cough and sputum,fatigue,poor appetite and other symptoms basically improved.The patient was given Paxlovid via nasal feeding for 2 courses without deterioration of liver and kidney function,diarrhea,nausea and vomiting,myalgia,chest tightness and other side effects,and was discharged from hospital with good recovery.CONCLUSION This case suggests that Paxlovid can be used cautiously in centenarians with renal insufficiency and two courses of treatment can be considered in patients with persistent positive nucleic acid.

关 键 词：COVID-19 Paxlovid CENTENARIANS Renal insufficiency Heart failure Lung infection Case report 

分 类 号：R563.1[医药卫生—呼吸系统]