特发性炎症性肌病心血管风险研究进展  

Advancements in the investigation of cardiovascular risk associated with idiopathic inflammatory myopa⁃thy

作　　者：陈向红 陈秀敏[1] 周颖燕[1] 李李 徐侦雄[1] CHEN Xianghong;CHEN Xiumin;ZHOU Yingyan;LI Li;XU Zhenxiong(The Second Clinical Medical College Affiliated to Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China)

机构地区：[1]广州中医药大学附属第二临床医学院,广东广州510405

出　　处：《实用医学杂志》2024年第19期2801-2805,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82274421);国家自然科学基金青年项目(编号:82305246);青年岐黄学者培育项目[编号:国中医药人教函(2022)256号];高水平大学专项(编号:A1-2601-22-415-013)。

摘　　要：特发性炎症性肌病是以肌肉炎症和多种肌肉外表现为特征的一组异质性自身免疫性疾病。其以肌无力、肌痛为典型的临床表现,可累及肺、皮肤、关节、胃肠道、心脏等多脏器。而心脏虽可累及,但不多见,且其临床表现隐匿,易被忽视。心脏损害是特发性炎症性肌病患者死亡和致残的重要原因之一,早期准确地识别心脏受累可改善患者预后。本文通过总结特发性炎症性肌病心脏受累可能的发病机制、临床表现、高危因素、早期诊断的生物标志物及影像学检查,以期提高临床医师对特发性炎症性肌病心脏受累的认识和诊断水平,达到早期治疗、终身管理,改善预后。The idiopathic inflammatory myopathies encompass a diverse array of autoimmune diseases,characterized by muscular inflammation and various extramuscular manifestations.These conditions have the poten-tial to impact multiple organs,including the lungs,skin,joints,gastrointestinal tract,and heart.The defining features of these conditions are muscle weakness and myalgia.Although cardiac involvement is infrequent,its clinical manifestations are subtle and easily overlooked.Cardiac damage represents a significant contributor to mortality and morbidity in patients with idiopathic inflammatory myopathy.Early and accurate identification of cardiac involve-ment may facilitate improved patient outcomes.This article provides an overview of the potential etiology,clinical presentations,risk factors,biomarkers,and imaging studies for early diagnosis of cardiac involvement in idio-pathic inflammatory myopathy.This review aims to enhance clinicians'understanding and diagnostic capabilities re-garding cardiac involvement in idiopathic inflammatory myopathy while promoting early intervention strategies for lifelong management and improved prognosis.

关 键 词：特发性炎症性肌病 心血管风险 危险因素 

分 类 号：R593.2[医药卫生—内科学]