肌注维生素D_(2)治疗高龄男性维生素D缺乏的疗效观察  

作　　者：邵丽丽 叶世佳 金力芳[1] 钱素凤[1] 应奇峰[1] 陈锦平[1] 边平达[1] 

机构地区：[1]浙江省人民医院(杭州医学院附属人民医院),310024

出　　处：《浙江临床医学》2024年第9期1322-1323,共2页Zhejiang Clinical Medical Journal

基　　金：浙江省医药卫生科技计划项目(2018KY222,2019KY015,2021KY459)。

摘　　要：目的观察肌注维生素D_(2)治疗高龄男性维生素D缺乏患者的疗效。方法选取2023年1月1日至1月31日高龄男性维生素D缺乏患者90例,采用随机数字表法分为观察组(45例)和对照组(45例),对照组仅坚持晒太阳,观察组在对照组基础上,肌注维生素D_(2)针(60万IU/月),治疗6个月。比较两组患者治疗后血清25(OH)D_(2)、25(OH)D_(3)、甲状旁腺激素(PTH)、血钙、血磷、尿钙、尿磷等水平。结果治疗后,两组患者血清25(OH)D_(2)、25(OH)D_(3)、尿钙、尿钙/肌酐和PTH比较,差异均有统计学意义(P<0.05)。结论维生素D_(2)注射液可明显提高高龄男性维生素D缺乏患者血清25(OH)D_(2)水平,然而可增加尿钙的排出。Objective To observe the efficacy of intramuscular injection of vitamin D_(2)in the treatment of senior male patients with vitamin D deficiency.Methods Ninety cases of senior male vitamin D deficiency patients were selected from 1 January 2023 to 31 January 2023,and were divided into the treatment group(45 cases)and the control group(45 cases)by using the method of random number table,the control group only adhered to sunbathing,and the treatment group was treated with intramuscular injection of vitamin D_(2)injection(600,000 IU/month)based on the control group for 6 months.Comparison of serum 25(OH)D_(2),25(OH)D_(3),parathyroid hormone(PTH),blood calcium,blood phosphorus,urinary calcium,urinary phosphorus and other levels in the two groups after treatment.Results After treatment,serum 25(OH)D_(2),25(OH)D_(3),urinary calcium,urinary calcium/creatinine and PTH were compared between the two groups of patients,and the differences were statistically significant(P<0.05).Conclusion Vitamin D_(2)injection can significantly increase serum 25(OH)D_(2)levels in elderly male vitamin D deficient patients,however,it can increase urinary calcium excretion.

关 键 词：老年人 25-羟基维生素D 尿钙 

分 类 号：R591.44[医药卫生—内科学]