黑地黄丸对慢性肾功能衰竭的作用机制研究进展  

Research progress of Black Rehmannia Pill on chronic renal failure

作　　者：吴俊燕 马超(综述) 赵平(审校)[1] Wu Junyan;Ma Chao;Zhao Ping(Department of Nephrology,Tai'an Traditional Chinese Medicine Hospital,Shandong Province,Tai'an 271000,China)

机构地区：[1]泰安市中医医院肾病科,山东泰安271000

出　　处：《疑难病杂志》2024年第10期1260-1263,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：山东省中医药科技项目(重点项目)(2021Z019)。

摘　　要：慢性肾功能衰竭是所有原发性或继发性肾损害出现的系列症状或代谢紊乱组合而成的综合征,临床以尿液异常、水代谢紊乱及电解质紊乱为主要表现。中医理论认为,脾的运化功能必得肾阳的温煦蒸化才能化生气血精微,而肾精必须依赖脾的运化精微滋养,才能不致生化无源。而慢性肾功能衰竭多由脾肾虚损导致,与先天不足、饮食不节、七情内伤、久病失治、房劳过度等多种因素耗伤正气有关,故治疗需将补脾益肾贯穿始终。黑地黄丸方以苍术为君,地黄为臣,大枣为佐,干姜为使,常被单一或联合西医治疗慢性肾功能衰竭,疗效颇佳。文章从调整胃肠激素紊乱、加强肠黏膜屏障、调节肠道菌群紊乱、调节脑—肠轴互动、保护肾功能、纠正肾性贫血方面等对黑地黄丸改善慢性肾功能衰竭的作用机制进行综述,以为该药物相关机制研究及临床应用提供参考。Chronic renal failure is a syndrome composed of a series of symptoms or metabolic disorders that occur in all primary or secondary kidney damage.Clinically,it is mainly characterized by abnormal urine,water metabolism disorders,and electrolyte imbalances.According to traditional Chinese medicine theory,the spleen's transport and transformation function requires the warm and steaming of kidney yang to generate qi,blood,and essence.The kidney essence must rely on the nourishment of the spleen's transport and transformation essence to prevent biochemical stagnation.Chronic renal failure is often caused by spleen and kidney deficiency,which is related to various factors such as congenital deficiencies,irregular diet,internal injuries to the seven emotions,prolonged illness without treatment,and excessive sexual activity that deplete the vital energy.Therefore,treatment should focus on nourishing the spleen and kidneys throughout the process.Black Rehmannia Pill is a common self-prepared traditional Chinese medicine,which uses Atractylodes macrocephala as the ruler,Rehmannia glutinosa as the minister,jujube as the accompaniment,and dried ginger as the agent.It is often used in modern medicine alone or in combination with Western medicine to treat chronic renal failure,and its efficacy is quite good.This article reviews the mechanism of Black Rehmannia Pill in improving chronic renal failure from the aspects of adjusting gastrointestinal hormone disorders,strengthening intestinal mucosal barrier,regulating intestinal microbiota disorders,regulating brain gut axis interaction,protecting renal function,and correcting renal anemia,in order to provide reference for the research and clinical application of this drug.

关 键 词：慢性肾功能衰竭 黑地黄丸 作用机制 研究进展 

分 类 号：R692.5[医药卫生—泌尿科学]