噬菌体疗法在伤口感染抗菌治疗中应用的研究进展  

Application of bacteriophage therapy in the antibacterial treatment for wound infections:a review

作　　者：仁礼欢 宋鉴[1] 殷丽梅[1] 丁秀萍 董芳 刁菊菊[1,2] 张露露 孙阿妮[1] Ren Lihuan;Song Jian;Yin Limei;Ding Xiuping;Dong Fang;Diao Juju;Zhang Lulu;Sun Ani(Department of Hospital Infection Management,Weifang People′s Hospital,Weifang 261000,China;Department of Infectious Diseases,Weifang People′s Hospital,Weifang 261000,China)

机构地区：[1]潍坊市人民医院感染管理办公室,潍坊261000 [2]潍坊市人民医院感染科,潍坊261000

出　　处：《中华创伤杂志》2024年第9期844-849,共6页Chinese Journal of Trauma

基　　金：山东省自然科学基金(ZR2023LZY012,ZR2022MH273);山东省医药卫生科技发展项目(202104070847);潍坊市卫生健康委员会科研项目(WFWSJK‑2024‑115)。

摘　　要：伤口感染继发于机械、热力、化学等因素导致的急、慢性伤口,不仅导致伤口愈合延迟,甚至可能造成死亡。抗菌药物长期或不合理使用会产生大量耐药菌,造成难治性伤口感染,导致治疗效果不佳,迫切需要有效的治疗方法。噬菌体能有效杀灭耐药菌,且具有良好的抗细菌生物膜活性(BBF),对真核细胞无杀伤作用,在治疗耐药菌伤口感染领域显示出巨大的潜力。但噬菌体抗BBF的机制仍不完全明确,且噬菌体在治疗伤口感染中的抗菌效果也存在差异。为此,笔者就噬菌体生物学特征及作用机制和相关疗法在伤口感染抗菌治疗中应用的研究进展进行综述,为噬菌体治疗伤口感染的研究与应用提供参考。Wound infections,secondary to acute and chronic wounds caused by mechanical,thermal,chemical factors,etc,not only delay wound healing but also may lead to mortality.The prolonged or inappropriate use of antibiotics lead to the growth of drug‑resistant bacteria,resulting in refractory wound infections and poor treatment outcomes,which highlights the urgent need for effective therapies.Bacteriophages show great promise in treating drug‑resistant wound infections due to their effectiveness in killing drug‑resistant bacteria,their good resistance against bacterial biofilm(BBF)and their absence of cytotoxicity to eukaryotic cells.However,the mechanisms underlying bacteriophages′resistance against BBF remain incompletely understood and their antibacterial efficacy for wound infections may also vary.For this purpose,the authors reviewed the biological characteristics and mechanisms of bacteriophages and their application in antibacterial therapies for wound infections,aiming to provide a reference for further research and application of bacteriophages in the treatment of wound infections.

关 键 词：伤口感染 软组织感染 细菌噬菌体 抗药性 

分 类 号：R63[医药卫生—外科学]