左氧氟沙星联合常规抗结核方案治疗肺结核的效果分析  

Effect Analysis of Levofloxacin Combined with Conventional Anti-Tuberculosis Regimen in Treatment of Pulmonary Tuberculosis

作　　者：王旭 Wang Xu(Department of Tuberculosis Emergency Medicine,Changchun Tuberculosis Hospital,Changchun 130000,Jilin Province,China)

机构地区：[1]长春市结核病医院结核急诊内科,吉林长春130000

出　　处：《中国社区医师》2024年第25期43-45,共3页Chinese Community Doctors

摘　　要：目的:分析左氧氟沙星联合常规抗结核方案治疗肺结核的效果。方法:选取2022年1月—2023年6月长春市结核病医院收治的80例肺结核患者作为研究对象,采用随机数字表法分为对照组和研究组,各40例。对照组实施常规抗结核方案治疗,研究组在对照组基础上给予左氧氟沙星治疗。比较两组肺功能、痰液转阴率、不良反应发生情况。结果:治疗前,两组第1秒用力呼气容积占用力肺活量比值(FEV1/FVC)、第1秒用力呼气容积(FEV1)比较,差异无统计学意义(P>0.05);治疗6个月后,两组FEV1/FVC、FEV1高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。治疗3、6个月后,两组痰液转阴率逐渐升高,且研究组高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:左氧氟沙星联合常规抗结核方案治疗肺结核的效果显著,可改善肺功能,促进痰液转阴,且用药安全性较高。Objective:To analyze the effect of levofloxacin combined with conventional anti-tuberculosis regimen in treatment of pulmonary tuberculosis.Methods:A total of 80 patients with pulmonary tuberculosis admitted to Changchun Tuberculosis Hospital from January 2022 to June 2023 were selected as the study subjects.They were divided into a control group and a study group using random number table method,with 40 cases in each group.The control group was treated with conventional anti-tuberculosis regimen and the study group was treated with levofloxacin on the basis of control group.The lung function,sputum negative conversion rate,and adverse reactions were compared between two groups.Results:Before treatment,there was no significant difference in the percentage of forced expiratory volume in the first second to forced vital capacity(FEV1/FVC)and the forced expiratory volume in the first second(FEV1)between two groups(P>0.05).After 6 months of treatment,FEV1/FVC and FEV1 in the two groups were higher than those before treatment,and FEV1/FVC and FEV1 in the study group were higher than those in the control group,with a statistically significant difference(P<0.05).After 3 months and 6 months of treatment,the sputum negative conversion rate in the two groups gradually increased,and the rate in the study group was higher than that in the control group,with a statistically significant difference(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Levofloxacin combined with conventional anti-tuberculosis regimen has significant effects in treatment of pulmonary tuberculosis,and can improve lung function,promote sputum conversion,and have a high medication safety.

关 键 词：肺结核 左氧氟沙星 异烟肼 利福平 乙胺丁醇 吡嗪酰胺 

分 类 号：R521[医药卫生—内科学]