cGAS-STING通路通过调节巨噬细胞参与骨折愈合的研究进展  

Research progress on the involvement of cGAS-STING pathway in fracture healing by regulating macrophages

作　　者：郑苗苗 吴楠 朱祥[2] 刘知晓 唐昊 ZHENG Miaomiao;WU Nan;ZHU Xiang;LIU Zhixiao;TANG Hao(University of Shanghai for Science and Technology,co-cultivate with Naval Medical University,Shanghai 200093,China;Department of Traumatic Orthopedics,Changhai Hospital,Naval Medical University(Second Military Medical University),Shanghai 200433,China;Department of Histology and Embryology,College of Basic Medical Sciences,Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]上海理工大学健康科学与工程学院海军军医大学联合培养班,上海200093 [2]海军军医大学(第二军医大学)长海医院创伤骨科,上海200433 [3]海军军医大学(第二军医大学)基础医学院组织胚胎学教研室,上海200433

出　　处：《安徽医药》2024年第11期2131-2134,共4页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(82172431)。

摘　　要：骨折愈合是一个复杂缓慢的动态过程,巨噬细胞是最早到达骨折部位的细胞之一。长期以来人们一直认为巨噬细胞参与损伤部位的初始炎症并有助于清创,它们在正常骨稳态和骨折愈合过程中调节骨再生中的关键作用也越来越受到重视。近年来研究发现,cGAS-STING通路是先天免疫和病毒防御中重要的DNA传感机制,越来越多证据表明cGAS-STING通路与巨噬细胞密切相关,所以cGAS-STING通路可能通过调节巨噬细胞极化类型来参与骨折愈合。因此了解骨折修复过程中cGASSTING通路参与调节巨噬细胞的机制,将为促进骨折修复提供新的思路和策略。Fracture healing is a complex and slow dynamic process,and macrophages are one of the first cells to arrive at the fracture site.It has long been thought that macrophages contribute to the initial inflammation and debridement at the site of injury,and the key role of macrophages in regulating bone regeneration during normal bone homeostasis and fracture healing is also receiving increasing attention.In recent years,studies have found that the cGAS-STING pathway is an important DNA sensing mechanism in innate immunity and virus defense,and more and more evidence shows that the cGAS-STING pathway is closely related to macrophages,so the cGASSTING pathway may function in fracture healing by regulating the polarization type of macrophages.Therefore,understanding the mech anism of cGAS-STING pathway involved in the regulation of macrophages in the process of fracture repair will provide new ideas and strategies for promoting fracture healing.

关 键 词：骨折愈合 cGAS-STING通路 巨噬细胞 破骨细胞 

分 类 号：R683[医药卫生—骨科学]