氢质子磁共振波谱分析在排尿困难伴有逼尿肌收缩乏力中的诊断价值  

Diagnostic value of hydrogen proton magnetic resonance spectroscopy techniques for the diagnosis of detrusor underactivity

作　　者：江轩 夏金翔 黄志文 徐忠乐 闫旭 张艳斌 席俊华 JIANG Xuan;XIA Jinxiang;HUANG Zhiwen;XU Zhongle;YAN Xu;ZHANG Yanbin;XI Junhua(Department of Urology,Anhui Medical University Affiliated Hefei Hospital(Hefei Second People's Hospital),Hefei,Anhui 230011,China;Medical Imaging Center,Anhui Medical University Affiliated Hefei Hospital(Hefei Second People's Hospital),Hefei,Anhui 230011,China;The Fifth Clinical Medical College,Anhui Medical University,Hefei,Anhui 230032,China)

机构地区：[1]安徽医科大学附属合肥医院(合肥市第二人民医院)泌尿外科,安徽合肥230011 [2]安徽医科大学附属合肥医院(合肥市第二人民医院)医学影像中心,安徽合肥230011 [3]安徽医科大学第五临床医学院,安徽合肥230032

出　　处：《安徽医药》2024年第11期2184-2187,共4页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(82000672);安徽省重点研发与开发项目(2022e07020062);合肥市卫健委应用医学项目(Hwk2022zd006)。

摘　　要：目的探索氢质子磁共振波谱分析技术在逼尿肌收缩乏力(DU)中的诊断价值。方法收集2022年7月至2023年7月合肥市第二人民医院非神经源性下尿路症状(LUTS)病人42例,根据尿动力学检查结果分为DU组20例和非DU组22例。所用设备为Siemens Prisma 3.0T磁共振成像系统。记录膀胱壁内胆碱(Cho)和肌酸(Cr)的峰值积分数据,并通过后处理软件得出Cho与Cr的峰值积分比值(Cho/Cr),进行组间比较。结果DU组Cho/Cr最大比值1.30,最小比值0.45,平均比值0.77±0.33,非DU组Cho/Cr最大比值1.62,最小比值0.53,平均比值1.16±0.33,DU病人Cho/Cr与非DU病人Cho/Cr差异有统计学意义(P<0.05),非DU组病人指标明显升高;而DU病人与非DU病人Cho差异无统计学意义(P>0.05)。结论膀胱壁逼尿肌Cho/Cr指标与膀胱功能有一定相关性,可能会成为DU病人的一种客观标志物。Objective To explore the diagnostic value of hydrogen proton magnetic resonance spectroscopy techniques for the diagnosis of detrusor underactivity(DU).Methods Patients with non-neurogenic lower urinary tract symptoms(LUTS)were collected in Hefei Second People's Hospital from July 2022 to July 2023 and divided into DU and non-DU groups based on urodynamic findings,with a total of 42 patients,including 20 DU patients and 22 non-DU patients.The equipment used was Siemens Prisma 3.0T magnetic resonance imaging system.Peak integral data of choline(Cho)and creatine(Cr)within the bladder wall were recorded and the peak integral ratio of Cho to Cr(Cho/Cr)was derived by post-processing software for comparison between groups.Results The DU group had a maximum Cho/Cr ratio of 1.30,a minimum ratio of 0.45,and an average ratio of 0.77±0.33.The non-DU group had a maximum Cho/Cr ratio of 1.62,a minimum ratio of 0.53,and an average ratio of 1.16±0.33.Statistical analysis showed a significant difference in Cho/Cr ratio between the DU group and the non-DU group(P<0.05),with the non-DU group showing a significantly higher index.However,there was no statistically significant difference in Cho values between the DU group and the non-DU group(P>0.05).Conclusion The bladder wall urethral muscle Cho/Cr index has a correlation with bladder function and may be an objective marker for DU patients.

关 键 词：排尿困难 膀胱逼尿肌 逼尿肌收缩乏力 下尿路症状 磁共振波谱成像 膀胱 

分 类 号：R445.2[医药卫生—影像医学与核医学] R691[医药卫生—诊断学]