宫颈癌组织中EZH2、LAG-3表达及与病理特征的相关性  

Expression of EZH2 and LAG-3 in cervical cancer tissue and their correlation with pathological features

作　　者：李学敏 吴莉莉 方琴 田静 Li Xuemin;Wu Lili;Fang Qin;Tian Jing(Hefei Third People's Hospital,Hefei,Anhui 230022,China)

机构地区：[1]合肥市第三人民医院,安徽合肥230022

出　　处：《齐齐哈尔医学院学报》2024年第19期1807-1812,共6页Journal of Qiqihar Medical University

基　　金：2019年度院级科研项目(SYKF201905)。

摘　　要：目的分析宫颈癌组织中Zeste增强子同源物2(EZH2)、淋巴细胞激活基因-3(LAG-3)表达及与病理特征的相关性。方法选择2013年5月—2023年11月本院收治的54例经病理确诊为宫颈癌并行宫颈根治术的患者作为观察组;并选取同期1477例宫颈良性病变患者作为对照组。比较两组患者EZH2、LAG-3表达水平,比较不同宫颈癌病理特征患者组织EZH2、LAG-3表达水平差异,分别采用单因素与多因素Logistic回归分析法筛选造成宫颈癌术后患者预后不良的危险因素。结果观察组EZH2、LAG-3阳性表达率相较于对照组均更高(P<0.05);临床分期在Ⅲ或Ⅳ期、分化程度为低中分化、浸润深度>3 mm、已发生脉管浸润和淋巴转移患者的EZH2、LAG-3阳性表达率相较于临床分期在Ⅰ或Ⅱ期、分化程度为高分化、浸润深度≤3 mm、未发生脉管浸润和淋巴转移的宫颈癌患者更高(P<0.05);随访6个月后,54例患者中6例患者发生预后不良,预后不良发生率为11.11%(6/54);预后不良组低中分化、浸润深度>3 mm、淋巴转移阳性、EZH2和LAG-3阳性表达占比相较于预后良好组均更高(P<0.05);(4)Logistic回归分析结果显示,低中分化程度、淋巴转移阳性、EZH2和LAG-3阳性表达是造成宫颈癌术后患者出现预后不良的危险因素(P<0.05)。结论宫颈癌患者组织EZH2、LAG-3阳性表达率较高,其表达水平与临床分期、分化程度、浸润深度、脉管浸润、淋巴转移病理特征密切相关;低中分化程度、淋巴转移阳性、EZH2和LAG-3阳性表达是造成宫颈癌患者预后不良的危险因素,临床在收治上述患者时应提前采取干预措施,谨防预后不良。Objective To analyze the expression of enhancer of zeste homolog 2(EZH2)and lymphocyte activation gene 3(LAG-3)in cervical cancer tissue and their correlation with pathological features.Methods A total of 54 patients diagnosed with cervical cancer and who underwent radical hysterectomy at our hospital between May 2013 and November 2023 were included as the observation group.Additionally,1477 patients with cervical benign lesions during the same period served as the control group.The expression levels of EZH2 and LAG-3 were compared between the two groups.The differences in EZH2 and LAG-3 expression levels in tissues of patients with varying pathological features of cervical cancer were also compared.Univariate and multivariate logistic regression analyses were used to identify risk factors associated with poor prognosis in cervical cancer patients post-surgery.Results The positive expression rates of EZH2 and LAG-3 in the observation group were significantly higher compared to the control group(P<0.05).Patients with clinical stageⅢorⅣ,low to moderate differentiation,infiltration depth>3 mm,and presence of lymphovascular space invasion and lymph node metastasis had higher EZH2 and LAG-3 positive expression rates compared to patients with clinical stageⅠorⅡ,high differentiation,infiltration depth≤3 mm,and without lymphovascular space invasion and lymph node metastasis(P<0.05).After a 6-month follow-up,6 out of 54 patients(11.11%)experienced poor prognosis.The poor prognosis group had a higher proportion of low to moderate differentiation,infiltration depth>3 mm,positive lymph node metastasis,and positive expression of EZH2 and LAG-3 compared to the good prognosis group(P<0.05).Logistic regression analysis indicated that low to moderate differentiation,positive lymph node metastasis,and positive expression of EZH2 and LAG-3 are risk factors for poor prognosis in cervical cancer patients post-surgery(P<0.05).Conclusions High positive expression rates of EZH2 and LAG-3 in cervical cancer tissues are closely

关 键 词：宫颈癌 Zeste增强子同源物2 淋巴细胞激活基因-3 病理特征 相关性 预后 

分 类 号：R713.44[医药卫生—妇产科学]