基于fMRI对双侧特发性耳鸣伴听力下降患者杏仁核亚区动态及静态功能连接变化的研究  

A study on the dynamic and static functional connectivity changes of amygdala subregions in patients with bilateral idiopathic tinnitus and hearing loss based on fMRI

作　　者：施玥 陈澜月 张祎[2] 马晓博 李薇 曲晓霞 王倩[1] 牛延涛[1] 刘兆会[1] SHI Yue;CHEN Lanyue;ZHANG Yi;MA Xiaobo;LI Wei;QU Xiaoxia;WANG Qian;NIU Yantao;LIU Zhaohui(Department of Radiology,Beijing Tongren Hospital,Capital Medical University,Beijing,100730,China;Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Ministry of Education,Beijing,100730,China)

机构地区：[1]首都医科大学附属北京同仁医院放射科,北京100730 [2]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,耳鼻咽喉头颈科学教育部重点实验室(首都医科大学),北京100730

出　　处：《中国耳鼻咽喉头颈外科》2024年第9期574-579,共6页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：国家自然科学基金(82071882);北京市自然科学基金(7222029);北京市教育委员会科技计划项目(KM202010025019)。

摘　　要：目的观察双侧特发性耳鸣伴听力下降(tinnitus and hearing loss,TINHL)患者杏仁核亚区静态功能连接(static functional connectivity,sFC)和动态功能连接(dynamic functional connectivity,dFC)特征改变。方法选取30例双侧TINHL患者和37例正常对照(NCs),进行静息态功能磁共振(fMRI)扫描,分析TINHL患者杏仁核八个亚区与全脑sFC和dFC的强度变化。结果两组被试的年龄、性别和受教育程度均无显著差异。与NCs组相比,TINHL组右侧基底外侧区杏仁核与右侧小脑脚1区,左侧基底外侧区杏仁核与左侧眶部额中回及左侧角回的sFC强度显著降低。TINHL组左侧杏仁核纹状体区与左侧楔前叶的dFC强度增高;左侧基底外侧区杏仁核与右侧角回,右侧浅表区杏仁核与右侧眶内额上回的dFC强度减低。结论杏仁核八个亚区中,双侧基底外侧区、左侧杏仁核纹状体区及右侧浅表区出现与其他脑区的异常功能连接改变,是引起TINHL患者情绪异常的重要区域。OBJECTIVE To observe the changes of static functional connectivity(sFC)and dynamic functional connectivity(dFC)of amygdala subregions in patients with bilateral idiopathic tinnitus and hearing loss(TINHL).METHODS The resting-state functional magnetic resonance imaging(fMRI)data of 30 patients with bilateral tinnitus and hearing loss and 37 normal controls(NCs)were collected to analyze the intensity changes of sFC and dFC in 8 subregions of amygdala and the whole brain in TINHL patients.RESULTS There were no significant differences in age,sex and education between the two groups.Compared with the NCs group,the sFC intensity of the right basolateral subregion and right cerebellar peduncle 1 region,the left basolateral subregion and left orbital medial frontal gyrus and left angular gyrus in TINHL group was significantly decreased.The dFC intensity of left amygdalostriatal subregion and left precuneus in TINHL group was increased,but the dFC intensity was reduced in the left basolateral subregion and right angular gyrus as well as between the right superficial subregion and right medial orbital of superior frontal gyrus.CONCLUSION Among the 8 subregions of amygdala,the bilateral basolateral subregions,the left amygdalostriatal subregion and the right superficial region shown abnormal functional connectivity with other regions of the brain,which are the important parts of emotional abnormalities in TINHL.

关 键 词：耳鸣 听力损失 磁共振成像 杏仁核 动态功能连接 功能磁共振 

分 类 号：R764.45[医药卫生—耳鼻咽喉科] R445.2[医药卫生—临床医学]