Hippo/Yap信号通路在调控听觉和前庭系统中的研究进展  

Progress of Research on Hippo/Yap Signaling Pathway in Regulation of Auditory System

作　　者：郝文丽 俞晨杰[1] 程诚 卢洁 邱悦 吉欣雅 钱晓云[1] 高下[1] HAO Wenli;YU Chenjie;CHENG Cheng;LU Jie;QIU Yue;JI Xinya;QIAN Xiaoyun;GAO Xia(Nanjing Drum Tower Hospital,Nanjing University Medical School Affiliated Hospital,Nanjing 210000,China)

机构地区：[1]南京大学附属鼓楼医院,南京210000

出　　处：《中华耳科学杂志》2024年第4期661-665,共5页Chinese Journal of Otology

基　　金：国家自然科学基金资助项目:82271173。

摘　　要：Hippo/Yap信号通路广泛参与听觉系统发育过程、听力损伤修复和听觉系统障碍。胚胎发育过程中对Yap的调控可能导致听觉器官的形态和功能缺陷。Hippo/Yap信号通路通过与多种信号分子相互作用,参与听力系统损伤或听觉系统疾病的相关进程,这些信号分子受JNK信号通路、Wnt信号系统和机械信号转导的影响。本文综述了听觉系统中Hippo/Yap信号通路的研究进展,为多种形式的听力损失的分子生物学过程和治疗提供了新的思路。The Hippo/Yap signaling pathway is extensively implicated in auditory system development,hearing injury repair,and auditory system disorders.The regulation of Yap during embryonic development may result in morphological and functional defects of the hearing organ.The Hippo/Yap signaling pathway is involved in processes related to hearing system injury and diseases by interacting with a wide range of signaling molecules,which are influenced by the JNK signaling pathway,the Wnt signaling system,and mechanical signal transduction.This review covers the development in Hippo/Yap signaling pathway research in regard to the auditory system,to hopefully provide novel ideas for understanding the molecular biological process and developing therapeutic therapies for various forms of hearing loss.

关 键 词：Hippo/Yap信号 听力损失 毛细胞再生 听力保护 

分 类 号：R764[医药卫生—耳鼻咽喉科]