肢体导联与胸导联心电图对异丙肾上腺素诱导大鼠心肌梗死的诊断价值  

Diagnostic value of limb lead and chest lead ECGs on isoproterenol-induced myocardial infarction in rats

作　　者：李昭蓉 侯艳群 何涛[1] 秦超[1] 张小华[1] 罗卿泉 LI Zhaorong;HOU Yanqun;HE Tao;QIN Chao;ZHANG Xiaohua;LUO Qingquan(Department of Electrocardiogram Diagnosis,1.the First Affiliated Hospital of Guangxi Medical University,Nanning Guangxi 530021;Liuzhou Workers'Hospital,Liuzhou Guangxi 545005,China)

机构地区：[1]广西医科大学第一附属医院心电诊断科,广西南宁530021 [2]柳州市工人医院心电诊断科,广西柳州545005

出　　处：《实用心电学杂志》2024年第5期448-453,共6页Journal of Practical Electrocardiology

基　　金：广西卫健委自筹经费科研课题(20200302);广西中医药药效研究重点实验室开放课题(19-050-39-K1)

摘　　要：目的 分析注射异丙肾上腺素(isoproterenol, ISO)法建立的大鼠心肌梗死模型各导联的心电图表现,探讨适用于该模型的判断心肌梗死是否形成的观测导联。方法 给20只大鼠皮下注射ISO,间隔24 h后再次给药,每24 h内各记录一次肢体、胸导联心电图,测量除aVR导联以外的各导联J点的偏移值,并与各自导联用药前及用药后比较。48 h后处死大鼠,并取心脏做病理检查。结果 第2天用药前V_(2)导联J点抬高较Ⅱ、Ⅲ、aVF导联明显(P<0.01),Ⅱ、Ⅲ、aVF导联两两比较差异无统计学意义(P>0.05)。结论 ISO法建立大鼠心肌梗死模型的梗死区域较分散,多个导联可出现J点抬高,其中以V_(2)导联最为明显。实验中可选择上述导联之一予以观测,亦可采用肢体、胸导联同步监测。Objective To analyze the ECG manifestations of each lead of myocardial infarction(MI)model in rats established by injection of isoproterenol(ISO),and to explore the observation leads suitable for this model to judge whether MI has been formed.Methods Twenty rats were injected with ISO subcutaneously,and then were given the drug again after 24 hours.ECGs of limb and chest leads were recorded every 24 hours,while the deviation value of J-point of each lead except that of lead aVR was measured,and compared with those before and after administration.After 48 hours,the rats were killed,and their hearts were obtained for pathological examination.Results On the 2nd day before medication,the elevation of J-point in lead V2 was more obvious than that in leadsⅡ,Ⅲand aVF(P<0.01),and there was no statistical difference of the value in pairwise comparison of leadsⅡ,Ⅲand aVF(P>0.05).Conclusion The infarct areas of MI model in rats established by ISO method are scattered;J-point elevation could appear in multiple leads,of which lead V2 is the most obvious.One of the above leads could be selected for observation in the experiment;limb and chest leads could also be monitored synchronously.

关 键 词：大鼠 心肌梗死 心电图 异丙肾上腺素 

分 类 号：R542.22[医药卫生—心血管疾病] R540.41[医药卫生—内科学]