血型不相容肝移植在成人急重症肝功能衰竭中的应用  

Application of ABO-incompatible liver transplantation in adult acute and severe liver failure

作　　者：杨世伟 谭海东[1] 刘立国[1] 刘笑雷[1] 司爽[1] 周瑞泉 刘天同 杨佩军 韩东冬 Yang Shiwei;Tan Haidong;Liu Liguo;Liu Xiaolei;Si Shuang;Zhou Ruiquan;Liu Tiantong;Yang Peijun;Han Dongdong(Liver Transplantation Center,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院肝脏移植中心,北京100029

出　　处：《实用器官移植电子杂志》2024年第5期390-393,共4页Practical Journal of Organ Transplantation(Electronic Version)

基　　金：中日友好医院高水平医院临床业务费专项(2023-NHLHCRF-LXYZ-01)。

摘　　要：目的急重症肝功能衰竭发展迅速,病死率极高,而肝移植手术可及时挽救患者生命。由于供体短缺,患者往往无法及时匹配上合适肝源。通过对血型不相容肝移植的应用探索能在一定程度上缓解肝源短缺的局面。方法对3例急重症肝功能衰竭患者行血型不相容肝移植,通过采用合适的预处理手段,观察患者术后的并发症及存活情况。结果术后3例患者均未出现急性排斥反应,2例患者均长期存活,其中1例患者早期出现胆道并发症并及时处理,1例患者出现严重感染而死亡。结论对于急重症肝功能衰竭的患者进行紧急血型不相容肝移植也能取得较好的效果。Objective Acute and severe liver failure progress rapidly with an extremely high mortality,while timely liver transplantation can save the patient's life.Due to the shortage of donors,patients often cannot match a suitable liver in time.Through the application of ABO-incompatible liver transplantation,the situation of liver shortage can be alleviated to a certain extent.Methods ABO-incompatible liver transplantation was performed on 3 patients with acute and severe liver failure.By adopting appropriate pretreatment methods,the postoperative complications and survival of the patients were observed.Results None of the 3 patients had acute rejection after the operation.Two patients survived for a long term.Among them,1 patient had biliary complications in the early stage and was treated in time,and 1 patient died due to severe infection.Conclusion For patients with acute and severe liver failure,emergency ABO-incompatible liver transplantation can also achieve good results.

关 键 词：肝功能衰竭 肝移植 血型不相容 

分 类 号：R657.3[医药卫生—外科学]