不同炎症反应程度慢性乙型肝炎患者血清ChE、PA及HBsAg检测价值分析  

Detection value of serum ChE,PA and HBsAg in patients with chronic hepatitis B and different degree of inflammatory response

作　　者：杨婷 Yang Ting(Department of Laboratory Medicine,Hengfeng Hospital of Traditional Chinese Medicine,Shangrao 334300,Jiangxi,China)

机构地区：[1]横峰县中医院检验科,江西上饶334300

出　　处：《四川生理科学杂志》2024年第10期2208-2210,共3页

摘　　要：目的:探究慢性乙型肝炎(Chronic Hepatitis B,CHB)不同炎症反应程度患者血清胆碱酯酶(Cholinesteras,ChE)、血清前白蛋白(Serum prealbumin,PA)及乙肝表面抗原(Hepatitis B surface Antigen,HBsAg)检测临床价值。方法:回顾性分析2021年7月至2023年7月我院收治的130例CHB患者临床资料,根据是否存在明显炎症分为G≥2组(n=86)及G<2组(n=44),根据炎症程度进一步分为轻度组(n=44)、中度组(n=40)和重度组(n=46),比较各组患者ChE、PA、HBsAg水平,采用受试者工作特征曲线(Receiver Operating Characteristic,ROC)下面积(Area Under Curve,AUC)对CHB炎症反应G≥2程度患者的检测价值。结果:G≥2组患者的ChE、PA、HBsAg水平低于G<2组,差异具有统计学意义(P<0.05);轻度组ChE、PA、HBsAg水平高于中度组、高于重度组,中度组ChE、HBsAg水平高于重度组,差异具有统计学意义(P<0.05);ChE、PA、HBsAg水平与炎症反应程度呈负相关;ROC结果显示:血清ChE、PA、HBsAg水平联合检测对CHB患者G≥2炎症反应程度的检测价值AUC 0.883高于单一检测为0.789、0.743、0.658,检测敏感度82.56%高于单一检测敏感度74.42%、70.93%和66.28%。结论:血清ChE、PA、HBsAg水平及三者联合检测均对慢性乙型肝炎不同炎症反应程度患者具有检测价值,值得临床参考。Objective:To explore clinical detection value of serum cholinesterase(ChE),prealbumin(PA)and hepatitis B surface antigen(HBsAg)in patients with chronic hepatitis B(CHB)and different degree of inflammatory response.Methods:A retrospective analysis was performed on the clinical data of 130 patients with CHB in the hospital between July 2021 and July 2023.According to presence or absence of inflammatory response,patients were divided into G≥2 group(n=86)and G<2 group(n=44).According to different degree of inflammatory response,patients were divided into mild group(n=44),moderate group(n=40)and severe group(n=46).The levels of ChE,PA and HBsAg in different groups were compared,and their detection value for G≥2 inflammatory response was analyzed by area under receiver operating characteristic(ROC)curve(AUC).Results:The levels of ChE,PA and HBsAg in G≥2 group were lower than those in G<2 group(P<0.05).The levels of ChE,PA and HBsAg in mild group were higher than those in moderate group and severe group,and levels of ChE and HBsAg in moderate group were higher than those in severe group(P<0.05).The levels of ChE,PA and HBsAg were negatively correlated with inflammatory response degree.The results of ROC curves analysis showed that AUC and sensitivity of serum ChE combined with PA and HBsAg for detecting G≥2 inflammatory response were 0.883 and 82.56%,higher than those of single index(0.789,0.743,0.658;74.42%,70.93%,66.28%).Conclusion:Serum ChE,PA,HBsAg and combined detection all have detection value in patients with chronic hepatitis B and different degree of inflammatory response,which is worthy of clinical reference.

关 键 词：慢性乙型肝炎 胆碱酯酶 前白蛋白 乙肝表面抗原 

分 类 号：R512.62[医药卫生—内科学]