不同剂量阿司匹林对妊娠期易栓症患者子宫动脉血流、易栓症标志物水平及妊娠结局的影响  

Effects of different doses of aspirin on uterine arterial blood flow,levels of thrombolytic markers,and pregnancy outcomes in patients with pregnancy susceptibility

作　　者：郭燕燕 张见平 钱跃磊 Guo Yan-yan;Zhang Jian-ping;Qian Yue-lei(Department of Obstetrics and Gynecology,Xinmi Hospital of Traditional Chinese Medicine,Xinmi 452370,Henan,China;Department of Pharmacy,Zhengzhou Coal Industry Group General Hospital,Xinmi 452370,Henan,China)

机构地区：[1]新密市中医院妇产科,河南新密452370 [2]郑州煤炭工业集团总医院药剂科,河南新密452370

出　　处：《四川生理科学杂志》2024年第10期2294-2296,共3页

摘　　要：目的:探讨不同剂量阿司匹林应用于妊娠期易栓症患者对其子宫动脉血流、妊娠结局、易栓症标志物水平的影响。方法:选取我科129例妊娠期易栓症患者,随机分为对照组和观察组。对照组(n=64)口服阿司匹林75 mg治疗,观察组(n=65)口服阿司匹林50 mg治疗,均在妊娠1 d后采用多普勒超声诊断仪检测子宫动脉搏动指数(Pulsatility index,PI)、阻力指数(Resistive index,RI)、收缩期峰值流速/舒张期流速(Peak systolic velocity/end diastolic velocity,S/D),采用希森美康CN-6000型全自动凝血分析仪检测血浆抗凝血酶Ⅲ、D-二聚体水平,采用发色底物法检测蛋白C、蛋白S活性,记录妊娠结局和药物不良反应。结果:两组患者治疗后PI、RI、S/D、蛋白C、血浆抗凝血酶Ⅲ、蛋白S、D-二聚体无统计学意义(P>0.05);观察组活产率高于对照组,不良反应发生率低于对照组(P<0.05)。结论:与75 mg阿司匹林比较,50 mg阿司匹林改善妊娠期易栓症患者子宫动脉血流和易栓症标志物水平效果相当,但其改善妊娠结局效果更优,安全性高。Objective:To investigate the effects of different doses of aspirin on uterine artery blood flow,pregnancy outcome,and the level of markers of thrombolytic disorder in patients with pregnancy susceptibility.Methods:A total of 129 patients with pregnancy susceptibility were randomly divided into a control group and an observation group.The control group(n=64)was treated with 75 mg of aspirin orally,while the observation group(n=65)was treated with 50 mg.In both groups,the pulsatility index(PI),resistive index(RI),and peak systolic velocity/end-diastolic velocity(S/D)of the uterine artery was measured using a Doppler ultrasound diagnostic instrument.Plasma antithrombin III and D-dimer levels were measured using a Sysmex CN-6000 fully automated coagulation analyzer,and protein C and protein S activities were measured using a chromogenic substrate method.The pregnancy outcomes and adverse drug reactions were recorded.Results:There were no significant differences in PI,RI,S/D,protein C,plasma antithrombin III,protein S,and D-dimer between the two groups after treatment(P>0.05).The live birth rate in the observation group was higher than that in the control group,and the incidence of adverse reactions was lower than that in the control group(P<0.05).Conclusion:Compared with 75 mg aspirin,50 mg aspirin has the same effect on improving the uterine artery blood flow and the level of markers of thromboembolism during pregnancy.However,it has a better effect on improving pregnancy outcomes and high safety.

关 键 词：不同剂量 阿司匹林 妊娠期易栓症 

分 类 号：R714.2[医药卫生—妇产科学]