血清GADA、CypA、SIRT1在糖尿病肾病中的表达及早期诊断价值分析  

Expression of serum GADA,CypA and SIRT1 in diabetic nephropathy and their value in early diagnosis

作　　者：吴朋 Wu Peng(Department of Clinical Laboratory,Jinshui General Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市金水区总医院检验科,河南郑州450000

出　　处：《四川生理科学杂志》2024年第10期2297-2299,共3页

摘　　要：目的:探究血清谷氨酸脱羧酶抗体(Glutamic acid decarboxylase,GADA)、亲环素A(Cyclophilin A,CypA)、Sirtuin-1(SIRT1)在糖尿病肾病(Diabetic nephropathy,DN)中的表达及早期诊断价值。方法:选取2020年1月至2023年1月期间本院收治的81例DN为研究组,另选取同期81例糖尿病患者为对照组。将DN患者根据肾功能损伤程度进一步分为微量蛋白尿组、大量蛋白尿组、肾功能损伤组。比较两组及不同程度肾损伤患者入院时血清GADA、CypA、SIRT1水平及联合诊断价值。结果:研究组血清GADA、CypA水平高于对照组,SIRT1水平低于对照组(P<0.05);不同程度肾损伤患者血清GADA、CypA水平比较:微量蛋白尿组<大量蛋白尿组<肾功能损伤组,SIRT1水平比较:肾功能损伤组<大量蛋白尿组<微量蛋白尿组(P<0.05);入院时血清GADA、CypA、SIRT1水平联合检测糖尿病肾病的AUC为0.840,最佳敏感度、特异度为88.89%、80.25%。结论:血清GADA、CypA、SIRT1水平与DN病情发展密切相关,可作为早期诊断的辅助指标。Objective:To investigate the expression of serum glutamate decarboxylase antibody(GADA),cycliphilin A(CypA)and Sirtuin-1(SIRT1)in diabetic nephropathy(DN)and its value in early diagnosis.Methods:81 patients with DN admitted to our hospital from January 2020 to January 2023 were selected as the study group,and 81 patients with diabetes during the same period were selected as the control group.The patients with DN were further divided into microalbuminuria group,macroalbuminuria group and renal injury group according to the degree of renal injury.Serum levels of GADA,CypA and SIRT1 were compared between the two groups and DN patients with different degrees of kidney injury at admission.Receiver operating characteristic curve(ROC)was used to analyze the value of combined diagnosis.Results:The levels of serum GADA and CypA in the study group were higher than those in the control group,and the levels of SIRT1 were lower than those in the control group(P<0.05).Comparison of serum GADA and CypA levels in patients with different degrees of renal injury:microproteinuria group<macroproteinuria group<renal function injury group;comparison of SIRT1 level:renal function injury group<macroproteinuria group<microproteinuria group(P<0.05);The AUC of the combined detection of serum GADA,CypA and SIRT1 levels in diabetic nephropathy at admission was 0.840,and the best sensitivity and specificity were 88.89%and 80.25%.Conclusion:Serum GADA,CypA and SIRT1 levels are closely related to the development of DN,and can be used as auxiliary indicators for early diagnosis.

关 键 词：谷氨酸脱羧酶抗体 亲环素A Sirtuin-1 糖尿病肾病 诊断价值 

分 类 号：R587.1[医药卫生—内分泌] R692[医药卫生—内科学]