盐酸溴己新联合哌拉西林-他唑巴坦对支气管扩张伴感染患者外周血NLR、IFN-γ水平的影响  

Influence of bromhexine hydrochloride combined with piperacillin-tazobactam on peripheral blood NLR and IFN-γlevels in patients with bronchiectasis and infection

作　　者：付尚阳 Fu Shang-yang(Poyang People's Hospital General Department,Shangrao 333100 Jiangxi,China)

机构地区：[1]鄱阳县人民医院全科,江西上饶333100

出　　处：《四川生理科学杂志》2024年第10期2339-2341,共3页

摘　　要：目的:探究盐酸溴己新联合哌拉西林-他唑巴坦对支气管扩张伴感染患者外周血中性粒细胞/淋巴细胞比值(Neutrophil-lymphocyte ratio,NLR)、干扰素-γ(Interferonγ,IFN-γ)水平的影响。方法:纳入我院2022年2月至2023年2月收治的支气管扩张伴感染患者,随机分为单一组40例(常规治疗及静脉滴注盐酸溴己新)和联用组40例(在单一组的基础上静脉滴注哌拉西林-他唑巴坦)。治疗前后,比较两组的中性粒细胞计数(Neutrophil count,NEUT)、淋巴细胞计数(Lymphocyte count,LYM),NLR和IFN-γ的水平。结果:联用组治疗总有效率高于单一组(P<0.05);与治疗前相比,各组患者NEUT、LYM、NLR、IFN-γ水平均明显降低(P<0.05),其中联用组更加显著(P<0.05);两组不良反应发生率无显著差异。结论:盐酸溴己新和哌拉西林-他唑巴坦联合用于治疗支气管扩张伴感染疗效显著,可有效改善NLR、IFN-γ水平,且安全性高。Objective:To investigate the influence of bromhexine hydrochloride combined with piperacillin-tazobactam on peripheral blood neutrophil-lymphocyte ratio(NLR)and interferon-γ(IFN-γ)levels in patients with bronchiectasis complicated with infection.Methods:Patients with bronchiectasis and infection in the hospital from February 2022 to February 2023 were included and divided into single group(40 cases,conventional treatment and intravenous infusion of bromhexine hydrochloride)and combined group(40 cases,intravenous infusion of piperacillin-tazobactam on the basis of single group).Before and after treatment,the levels of neutrophil count(NEUT),lymphocyte count(LYM),NLR and the levels of IFN-γwas compared between the two groups.Results:The total effective rate of treatment in combined group was higher than that in the single group(P<0.05).Compared with before treatment,the levels of NEUT,LYM,NLR and IFN-γin both groups were significantly decreased(P<0.05),and the changes in combined group were more significant(P<0.05).The incidence of adverse reactions of two groups hadn’t significant differences(P>0.05).Conclusion:Bromhexine hydrochloride combined with piperacillin-tazobactam has significant efficacy in the treatment of bronchiectasis with infection,and can effectively improve the levels of NLR and IFN-γ,with high safety.

关 键 词：盐酸溴己新 哌拉西林-他唑巴坦 支气管扩张伴感染 中性粒细胞/淋巴细胞比值 干扰素-Γ 

分 类 号：R562.2[医药卫生—呼吸系统]