基于《中华医方》的骨折药膏外治组方规律及敷溶介质研究  

Study on Rules of External Treatment and Application Medium of Fracture Ointment Based on Chinese Medical Formulas

作　　者：张磊[1] 梁诗韵 刘芊含 杨婷媛 王东 ZHANG Lei;LIANG Shiyun;LIU Qianhan;YANG Tingyuan;WANG Dong(School of Medicine,Jianghan University,Wuhan 430056,Hubei,China)

机构地区：[1]江汉大学医学部,湖北武汉430056

出　　处：《江汉大学学报（自然科学版）》2024年第5期52-61,共10页Journal of Jianghan University：Natural Science Edition

基　　金：国家级大学生创新创业训练计划项目(202011072018);江汉大学校级科研资助计划项目(2021yb142)。

摘　　要：目的基于R软件对《中华医方》中药膏外治骨折的方药信息进行数据挖掘,分析中药药膏外治骨折的用药规律。方法从《中华医方》中提取药膏外治骨折的方药信息,采用Excel软件对方药信息进行录入,建立“《中华医方》药膏外治骨折的方药数据库”,采用R软件对药膏处方进行频数分析、相关分析、关联规则分析和聚类分析。结果共纳入药膏处方103首,中药246味,累积使用频次931次。其中,使用频次≥10次的中药有23味,累积使用频次388次(41.68%);排名前5位的中药依次为乳香、没药、当归、肉桂和白芷;中药功效分类以活血化瘀药、清热药和补虚药为主,药性以温性为主,药味以辛、苦味为主,归经以肝、脾、心和肾经为主;相关系数较高的前5位中药组合多为活血化瘀药和清热药;统计药膏敷溶介质使用频次前3位依次为酒、生姜汁和醋;组方经关联规则分析得到核心中药组合16个,系统聚类分析共得到中药聚类组合4个。结论药膏外治骨折以乳香、没药、当归和土鳖虫为核心中药组方,以消肿止痛,活血化瘀和补肾强筋健骨为治疗原则;经数据挖掘技术得出的用药规律对药膏外治骨折的临床用药具有一定参考价值,也可为新药研发提供参考。Objective To analyze the prescription and medicine information of Chinese Medical Formulas for the external treatment of fracture based on R software,and to analyze the prescription and medicine pattern of the external treatment of fracture by Chinese medicine cream.Methods The prescription information of ointment for external treatment of bone fracture was extracted from Chinese Medical Formulas,Excel software was used to enter the information of the ointment to establish a″database of Chinese Medical Formulas for external treatment of bone fracture by ointment″,and R software was used to analyze the frequency,correlation,association rule,and cluster analyses of the ointment prescriptions.Results A total of 103 ointment prescriptions with 246 Chinese herbs were included,and the cumulative frequency of use was 931.Among them,there were 23 Chinese herbs with a usage frequency≥10 times,with a cumulative usage frequency of 388 times(41.68%).The top 5 herbal medicines were Ruxiang(Olibanum),Moyao(Myrrha),Danggu(i Angelicae Sinensis Radix),Rougui(Cinnamomi Cortex),and Baizhi(Angelicae Dahuricae Radix)in order.The efficacy of herbal medicines was mainly classified as activating blood circulation and resolving blood stasis,clearing heat,and tonifying deficiency;the medicinal properties were mainly warm;the taste was mainly pungent and bitter;and the meridians were mainly liver,spleen,heart,and kidney.The top 5 herbal combinations with higher correlation coefficients were mostly blood activators and heat-clearing drugs.The top 3 selected added media were wine,ginger juice and vinegar in order.16 core herbal combinations were obtained by association rule analysis,and 4 herbal clustering combinations were obtained by systematic clustering analysis.Conclusion The core herbal formulas for external treatment of fracture with Ruxiang(Olibanum),Moyao(Myrrha),Danggu(i Angelicae Sinensis Radix),and Tubiechong(Eupolyphaga)are based on the principles of reducing swelling and pain,activating blood stasis,and tonifying the kidn

关 键 词：骨折 药膏 用药规律 数据挖掘 R软件 

分 类 号：R289.6[医药卫生—方剂学] R274[医药卫生—中药学]