镍催化的β-溴氨基酸酯的交叉偶联反应的研究  

Study on Cross Coupling Reaction ofβ-Bromoamino Acid Esters Catalyzed by Nickel

作　　者：孙骞 刘银玲 李鑫雨 唐石[1] SUN Qian;LIU Yinling;LI Xinyu;TANG Shi(College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,China)

机构地区：[1]吉首大学化学化工学院,湖南吉首416000

出　　处：《化工技术与开发》2024年第10期19-22,共4页Technology & Development of Chemical Industry

摘　　要：本文探究了一种β-溴氨基酸酯与烯烃磺酸酯的亲电交叉偶联反应。合成路线以丝氨酸甲酯盐酸盐为原料,先经过胺醛缩合、亲电取代、Appel溴化等一系列反应制得中间产物,再通过亲电交叉偶联反应得到目标产物2-(烯丙基(4-氯苄基)氨基)-3-(4-氯苯基)丙酸甲酯。该反应的原料价廉易得,合成路线简洁,产物具有高效性和高区域选择性,实验结果可为氨基酸的修饰提供一条新途径。In this article,the electrophilic cross coupling reaction betweenβ-bromoamino acid ester and olefin sulfonate ester was explored.The synthesis route applied serine methyl ester hydrochloride as the raw material,which first undergoed amine aldehyde condensation,electrophilic substitution intermediate products were obtained through a series of reactions such as Appel bromination,and the target product 2-(allyl(4-chlorobenzyl)amino)-3-(4-hlorophenyl)propionate methyl ester was obtained through electrophilic cross coupling reaction.The raw materials of this reaction were inexpensive and readily available,the synthesis route was simple,and the product had high efficiency and high regional selectivity.

关 键 词：氨基酸衍生物 交叉偶联反应 镍催化 

分 类 号：O621.251[理学—有机化学]