动脉粥样硬化痰湿证动物模型的构建与评价  

Construction and Evaluation of Animal Model with Atherosclerosis and Phlegm-dampness Syndrome

作　　者：孙海洋 任芷萱 赵稳 程骁[1,2,3] 李岩 孙景波[1,2,3] SUN Haiyang;REN Zhixuan;ZHAO Wen;CHENG Xiao;LI Yan;SUN Jingbo(The Second Clinical School of Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;State Key Laboratory of Dampness Syndrome of Chinese Medicine,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120 Guangdong,China;Guangdong Provincial Key Laboratory of Research on Emergency in Traditional Chinese Medicine,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120 Guangdong,China;Guangxi International Zhuang Medical Hospital,Nanning 530201 Guangxi,China)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510006 [2]广东省中医院省部共建中医湿证国家重点实验室,广东广州510120 [3]广东省中医院广东省中医急症研究重点实验室,广东广州510120 [4]广西国际壮医医院,广西南宁530201

出　　处：《中药新药与临床药理》2024年第10期1483-1491,共9页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家重点研发计划中医药专项课题(2019YFC1708601);省部共建中医湿证国家重点实验室专项(SZ2021ZZ14,SZ2023ZZ04);广东省自然科学基金面上项目(2024A1515011472);国家自然科学基金资助项目(82160946)。

摘　　要：动脉粥样硬化(Atherosclerosis,AS)是心脑血管疾病如心肌梗塞、脑卒中等高致死率疾病的重要病理特征。痰湿因素被认为是AS缠绵难愈,且诱导并发症发生的重要病机,建立具有中医特色的痰湿证AS动物模型及客观评价体系是现代中西医结合心脑血管疾病研究的重要内容,对中医药防治心脑血管疾病具有重要意义。该文对AS痰湿证的中西医科学内涵进行梳理,全面地总结实验动物模型构建及评价现状,分析其存在的问题,并对模型的构建因素、评价指标等进行探讨,以期建立规范化、标准化的AS痰湿证动物模型。Atherosclerosis(AS)is an important pathological feature of cardiovascular diseases such as myocardial infarction,stroke and other highly fatal diseases.Phlegm and dampness are considered to be an important pathogenesis of AS,which is difficult to heal and can cause complications.The establishment of an animal model with AS and phlegm-dampness syndrome,which could reflect the features of traditional Chinese medicine(TCM),and objective evaluation system are an important element of modern integrated TCM and western medicine research on cardiovascular diseases.It is of great significance for TCM to prevent and treat cardiovascular diseases.This article summarizes the scientific connotations of traditional Chinese and western medicine for AS and phlegmdampness syndrome,comprehensively summarizes the current status of construction and evaluation in experimental animal model,analyzes the problems of current model,and discusses the factors of model construction and evaluation.Our aim is to establish normalized and standardized animal model with AS of phlegm-dampness syndrome.

关 键 词：动脉粥样硬化 痰湿证 病证结合 实验动物模型 

分 类 号：R285.5[医药卫生—中药学]