补肾方剂治疗阿尔兹海默病的临床及药理机制研究进展  

Progress of Clinical and Pharmacological Mechanisms of Kidney-tonifying Formula for the Treatment of Alzheimer’s Disease

作　　者：肖萌 张晓莲 刘伟 杨金娜 王文佳 胡蕴慧 方坚松[1] XIAO Meng;ZHANG Xiaolian;LIU Wei;YANG Jinna;WANG Wenjia;HU Yunhui;FANG Jiansong(Science and Technology Innovation Center of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Tasly Pharmaceutical Group Co.,Ltd.,Tianjin 300410,China)

机构地区：[1]广州中医药大学科技创新中心,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405 [3]天士力医药集团股份有限公司,天津300410

出　　处：《中药新药与临床药理》2024年第10期1628-1636,共9页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(82074278)。

摘　　要：阿尔茨海默病(AD)是一种常见的神经退行性疾病,其发病率逐年增长,目前还没有理想的治疗手段,已经成为全球范围内的公共卫生难题。中医认为肾虚是伴随着AD进程的恶化及证候时序演化的关键证候要素,补肾填精益髓是中医治疗痴呆的根本治法。临床研究表明补肾方剂能显著改善轻、中度AD患者的认知功能和日常生活自理能力,且无明显的不良反应发生。其作用机制可能与保护神经,降低脑β淀粉样蛋白(Aβ)水平,抑制炎症因子激活及抗氧化应激等有关。该文综述了补肾方剂治疗AD的临床及药理研究进展,从中医理论及现代医学研究方面探讨了补肾方剂防治AD的优势和不足,以期为中医补肾疗法防治神经退行性疾病提供参考。Alzheimer’s disease(AD)is a common neurodegenerative disease with increasing incidence rate.Up to now,there is no ideal treatment for AD.It has become a public health problem worldwide.Traditional Chinese medicine(TCM)believes that kidney deficiency is the key symptomatic element of deterioration and temporal progression symptoms,accompanied by the AD process.The treatment of tonifying kidneys,supplementing essence and replenishing marrow is the fundamental method for AD in TCM.Clinical studies have shown that kidneytonifying formula can significantly improve the cognitive function and daily ability of patients with mild and moderate AD and have no obvious adverse reactions.Its mechanism of action may be related to the protection of nerves,reduction ofβ-amyloid(Aβ)level in the brain,inhibition of inflammatory factors activation and anti-oxidative stress.Besides reviewing the clinical and pharmacological research progress of kidney-tonifying formula for AD,this article also discusses the advantages and shortcomings of kidney-tonifying formula in the prevention and treatment of AD based on TCM theory and modern medical research.The aim of this study is to provide references of kidney nourishing therapy in TCM for the prevention and treatment of neurodegenerative diseases.

关 键 词：阿尔茨海默病 补肾方剂 临床研究 药理研究 作用机制 

分 类 号：R285.6[医药卫生—中药学] R285.5[医药卫生—中医学]