倍半萜类化合物的心血管保护作用与机制研究进展  

Advances in cardiovascular protective effect and mechanism of sesquiterpenoids

作　　者：何永芸 胡明霞 姚玥 莫晓丹 黄安 杨秀芬 HE Yong-yun;HU Ming-xia;YAO Yue;MO Xiao-dan;HUANG An;YANG Xiu-fen(School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200;Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Nanning 530200;Key Laboratory of Traditional Chinese Medicine Neuro-Metabolism and Immunopharmacology of Guangxi Education Department,Nanning 530200)

机构地区：[1]广西中医药大学药学院,南宁530200 [2]广西壮瑶药重点实验室,南宁530200 [3]广西高校中药神经-代谢及免疫药理重点实验室,南宁530200

出　　处：《中南药学》2024年第10期2710-2716,共7页Central South Pharmacy

基　　金：广西自然科学基金项目(No.2020GXNSFAA297165);广西壮瑶药重点实验室建设项目计划(No.GXZYZZ2022-08);广西中医药大学广西一流学科(中药学)建设开放课题(No.2019XK122)。

摘　　要：倍半萜类化合物结构骨架类型多样,广泛存在于自然界中,并具有多种多样的生理活性,在保护心血管方面发挥重要作用。目前,倍半萜类化合物主要具有改善心肌肥厚、改善心肌缺血、减轻心肌梗死、保护内皮细胞损伤、抗动脉粥样硬化等生理活性,通过调节多种途径发挥保护心血管作用,如抑制氧化应激反应及调控NF-κB、PI3K/Akt、ERK1/2、TGF-β1/Smad等相关信号通路。本文综述该类化合物对心血管的保护作用及其机制研究,为倍半萜的进一步开发利用提供参考价值。Sesquiterpenoids have many structural skeletons and are widely distributed in the nature,with various physiological activities and playing important roles in protecting the cardiovascular system.Sesquiterpenoids mainly improve myocardial hypertrophy,ameliorate myocardial ischaemia,attenuate myocardial infarction,protect against endothelial cell damage and atherosclerosis.These compounds exert cardiovascular protective effects through various pathways,including inhibition of oxidative stress and modulation of related signalling pathways,such as NF-κB,PI3K/Akt,ERK1/2,and TGF-β1/Smad.This paper reviewed the cardiovascular protective effects of these compounds and their mechanism for further development sesquiterpenes.

关 键 词：倍半萜类 心血管疾病 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学] R286[医药卫生—中医学]