陕西省安康市1058例新生儿脐带血麻疹抗体水平调查  

Measles virus antibody levels in cord blood of 1058 newborns in Ankang city of Shaanxi Province

作　　者：万春阁 戴小强 罗延琪 向琳 陈磊 付妍妍 Wan Chunge;Dai Xiaoqiang;Luo Yanqi;Xiang Lin;Chen Lei;Fu Yanyan(Department of Immunization Program,Ankang City Center for Disease Control and Prevention,Shaanxi 725000,China)

机构地区：[1]陕西省安康市疾病预防控制中心免疫规划科,安康725000

出　　处：《中华微生物学和免疫学杂志》2024年第9期809-813,共5页Chinese Journal of Microbiology and Immunology

基　　金：陕西省科技厅重点研发计划重点产业创新链(群)项目(2022ZDXM-SF-01)。

摘　　要：目的通过对安康市新生儿脐带血麻疹抗体水平进行检测和分析,探讨麻疹预防控制措施和策略。方法于2023年1—12月,选取安康市10所县级综合医院孕产妇1058名,采集新生儿脐带血,ELISA检测麻疹IgG抗体,采用SPSS 21.0软件分析抗体阳性率及影响因素。结果调查对象麻疹IgG抗体总阳性率为89.22%(944/1058),麻疹IgG抗体几何平均浓度(geometric mean concentration,GMC)为570.26 mIU/ml。≤20、21~25、26~30、31~35、≥36岁孕产妇新生儿脐带血麻疹IgG抗体阳性率分别为91.07%(51/56)、90.27%(232/257)、89.54%(351/392)、88.12%(230/261)、86.96%(80/92)(χ^(2)=1.355,P=0.852);多因素Logistic回归模型分析显示,胎龄≥37周的孕产妇新生儿脐带血麻疹抗体阳性率高于<37周孕产妇[OR(95%CI):0.403(0.262~0.622)],出生体重为3.0~3.5 kg的新生儿脐带血麻疹抗体阳性率高于<3 kg、>3.5 kg新生儿[OR(95%CI):0.868(0.462~1.629)、1.765(1.087~2.865)]。结论新生儿脐带血麻疹IgG抗体阳性率和GMC随孕产妇年龄增大而呈现下降趋势,建议育龄妇女孕前开展含麻疹成分疫苗补充免疫。ObjectiveTo analyze the levels of antibody to measles virus in cord blood of newborns in Ankang city,and provide reference for the development of measles prevention and control measures and strategies.MethodsFrom January to December,2023,1058 pregnant women from 10 county-level general hospitals in Ankang city were recruited in this study.Neonatal umbilical cord blood samples were collected for detecting IgG antibody against measles with ELISA.SPSS 21.0 software was used to analyze the positive rate of antibody to measles virus and the influencing factors.ResultsThe overall positive rate of IgG antibody to measles virus was 89.22%(944/1058),and the geometric mean concentration(GMC)was 570.26 mlU/ml.The positive rates of IgG antibody against measles virus in umbilical cord blood of neonates born to women aged≤20,21-25,26-30,31-35,and≥36 years old were 91.07%(51/56),90.27%(232/257),89.54%(351/392),88.12%(230/261),and 86.96%(80/92),respectively(χ^(2)=1.355,P=0.852).Multivariate logistic regression analysis showed that the positive rate of IgG antibody against measles virus in umbilical cord blood samples was higher in neonates with gestational age≥37 weeks than in those with gestational age<37 weeks[OR(95%CI):0.403(0.262-0.622)].Besides,the positive rate was also higher in newborns with a birth weight of 3.0-3.5 kg than in those with birth weight<3 kg or≥3.5 kg[OR(95%CI):0.868(0.462-1.629),1.765(1.087-2.865)].ConclusionsThe positive rate and the GMC of IgG antibody to measles virus in neonatal umbilical cord blood decrease with maternal age.It is recommended that women of childbearing age should receive supplementary immunization with measles-containing vaccine before pregnancy.

关 键 词：麻疹 抗体水平 影响因素 新生儿脐带血 

分 类 号：R722.1[医药卫生—儿科]