细胞代谢在病毒与宿主互作中的作用  

Influence of cell metabolism on virus-host interaction

作　　者：王晓慧 蒋钰玉 丁莹莹 刘星光 Wang Xiaohui;Jiang Yuyu;Ding Yingying;Liu Xingguang(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Department of Pathogen Biology,National Key Laboratory of Immunity&Inflammation,Naval Medical University,Shanghai 200433,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]海军军医大学基础医学院病原生物学教研室,免疫与炎症全国重点实验室,上海200433

出　　处：《中华微生物学和免疫学杂志》2024年第9期814-821,共8页Chinese Journal of Microbiology and Immunology

基　　金：上海市"科技创新行动计划"实验动物研究领域项目(23141902300)。

摘　　要：细胞代谢是生命的基本特征之一,宿主代谢状态与病毒感染过程及结局密切相关。一方面,病毒可以利用宿主细胞中的代谢产物完成生命周期,当病毒颗粒吸附到易感细胞表面并进入细胞后,宿主细胞合成的一系列生物分子参与病毒在细胞内运输过程,使病毒完成其复制周期,并感染更多的细胞;另一方面,代谢反应与代谢物可以在病毒感染的各个阶段调控宿主抗病毒反应,从而影响病毒感染的结局。因此,细胞代谢是影响病毒感染及宿主抗病毒应答的关键。本文将分别从病毒在生物体内复制周期的6个阶段阐述细胞代谢在病毒与宿主互作中的作用。Cell metabolism is one of the basic characteristics of life,and the host metabolic state is closely related to the process and outcome of viral infection.Viruses can use the metabolites in host cells to complete the life cycle.When the virus particles are adsorbed onto the surface of the susceptible cells and enter the cells,a series of biomolecules synthesized by the host cells are involved in the intracellular transport of the virus.Thus,the virus completes its replication cycle and infects more cells.Besides,metabolic reactions and metabolites can regulate the host antiviral responses at various stages of viral infection,thus affecting the outcome of viral infection.Therefore,cell metabolism plays key roles in affecting viral infection and host antiviral responses.In this paper,the effects of cell metabolism on the interaction between viruses and host cells will be described from the six stages of virus replication cycle in vivo.

关 键 词：细胞代谢 病毒复制 抗病毒反应 病毒-宿主互作 

分 类 号：R373[医药卫生—病原生物学]