银杏提取物对老年突发性耳聋患者血流变学及凝血功能的影响  

Effect of Ginkgo biloba extract on hemorheology and coagulation function in elderly patients with sudden deafness

作　　者：熊剑丁 谢海涛[1] 魏小林 XIONG Jianding;XIE Haitao;WEI Xiaolin(Department of Otolaryngology Head and Neck surgery,Fengcheng People's Hospital,Fengcheng,Jiangxi,331100,China)

机构地区：[1]丰城市人民医院耳鼻咽喉头颈外科,江西丰城331100

出　　处：《当代医学》2024年第15期39-43,共5页Contemporary Medicine

摘　　要：目的探究银杏提取物对老年突发性耳聋患者血流变学及凝血功能的影响。方法选取2020年1月至2023年3月丰城市人民医院接诊的100例老年突发性耳聋患者作为研究对象,按照随机抽签法分为对照组与观察组,每组50例。对照组予以常规对症治疗,观察组在对照组基础上采用银杏提取物治疗,比较两组临床疗效、血流变学指标、凝血功能指标、听阈值、用药安全性。结果观察组治疗总有效率为92.0%,高于对照组的74.0%,差异有统计学意义(P<0.05)。用药10d后,两组血浆黏度、血细胞比容、全血黏度高切、全血黏度低切水平均低于用药前,且观察组低于对照组,差异有统计学意义(P<0.05)。用药10 d后,两组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均长于用药前,纤维蛋白原(Fg)水平低于用药前,且观察组PT、APTT均长于对照组,Fg水平低于对照组,差异有统计学意义(P<0.05)。用药10 d后,两组平均纯音听阈、高频区听阈、低频区听阈值均低于用药前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率差异比较差异无统计学意义。结论银杏提取物治疗老年突发性耳聋的临床疗效确切,利于改善患者血流变学、凝血功能,促进听阈值恢复,且安全性较高,值得临床推广应用。Objective To explore the effect of Ginkgo biloba extract on hemorheology and coagulation function in elderly patients with sudden deafness.Method 100 elderly patients with sudden deafness who were admitted to Fengcheng People's Hospital from January 2020 to March 2023 were selected as the research subjects,and they were divided into the control group and the observation group according to random drawing,with 50 cases in each group.The control group was treated with routine symptomatic treatment,while the observation group was treated with Ginkgo biloba extract on the basis of the control group,the clinical efficacy,hemorheology index,coagulation function index,hearing threshold and drug safety were compared between the two groups.Result The total effective rate in the observation group was 92.0%,which was higher than 74.0%in the control group,and the difference was statistically significant(P<0.05).After 10 d of medication,the plasma viscosity,hematocrit,whole blood viscosity high cut and whole blood viscosity low cut levels of the two groups were lower than those before medication,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).After 10 d of medication,the prothrombin time(PT)and activated partial thromboplastin time(APTT)of the two groups were longer than those before medication,and the fibrinogen(Fg)level was lower than that before medication,and the PT and APTT in the observation group were longer than those in the control group,and the Fg level was lower than that in the control group,and the differences were statistically significant(P<0.05).After 10 d of treatment,the average pure tone hearing threshold,high frequency region hearing threshold and low frequency region hearing threshold of the two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).There was no difference in the incidence of adverse reactions between the two groups.Conclus

关 键 词：银杏提取物 老年突发性耳聋 血流变学 凝血功能 

分 类 号：R285[医药卫生—中药学]