急性ST段抬高型心肌梗死PCI术后无复流现象的研究进展  

Research progress on no-reflow phenomenon after PCI surgery in patients with acute ST-elevation myocardial infarction

作　　者：孙佳雯 李艳芳[2] Sun Jiawen;Li Yanfang(Changzhi Medical College,Changzhi,Shanxi 046000,China;Heji Hospital Affiliated to Changzhi Medical College,Changzhi,Shanxi 046000,China)

机构地区：[1]长治医学院,山西长治046000 [2]长治医学院附属和济医院

出　　处：《齐齐哈尔医学院学报》2024年第18期1776-1780,共5页Journal of Qiqihar Medical University

摘　　要：冠状动脉无复流现象(NRP)是ST段抬高型心肌梗死(STEMI)患者再灌注治疗后的常见现象。虽然STEMI患者的梗死相关动脉在PCI期间得到有效血运重建,但可能无法在心肌组织中实现有效的再灌注。尽管发病机制尚不清楚,但已经提出了几种假设,包括局部血小板活化、微血管痉挛以及缺血或再灌注损伤导致的远端微血管血栓栓塞。这种现象严重影响了STEMI患者的临床获益及远期预后,为疾病的治愈带来了难题。本文通过收集、整理最新文献资料,对STEMI患者PCI术后发生NRP的预测因素、药物及非药物治疗进行综述。The no-reflow(NRP)phenomenon in the coronary arteries is a common occurrence following reperfusion therapy in patients with ST-segment elevation myocardial infarction(STEMI).Despite effective revascularization of the infarct-related artery during percutaneous coronary intervention(PCI)in STEMI patients,effective reperfusion in the myocardial tissue may not be achieved.Although the pathogenesis remains unclear,several hypotheses have been proposed,including local platelet activation,microvascular spasm,and thromboembolism in distal microvasculature caused by ischemia or reperfusion injury.This phenomenon significantly impacts the clinical benefits and long-term prognosis of STEMI patients,posing challenges for disease management.This review synthesizes the latest literature to examine predictive factors for NRP post-PCI in STEMI patients,as well as pharmacological and non-pharmacological treatments.

关 键 词：急性ST段抬高型心肌梗死 经皮冠状动脉介入治疗 无复流现象 预测因素 

分 类 号：R542.22[医药卫生—心血管疾病]