性激素指标在接受体外受精-胚胎移植的多囊卵巢综合征不孕患者中的表达及临床意义  

Expression and Clinical Significance of Sex Hormone Indicators in IVF-ET Patients with PCOS Infertility

作　　者：潘亚晶[1] 董玉倩 陈素洁 Pan Ya-jing;Dong Yuqian;Chen Sujie(Laboratory Department,The First Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan,453100,China)

机构地区：[1]新乡医学院第一附属医院检验科,河南新乡453100

出　　处：《黑龙江医学》2024年第19期2373-2376,共4页Heilongjiang Medical Journal

摘　　要：目的:探讨性激素指标在接受体外受精-胚胎移植(IVF-ET)的多囊卵巢综合征(PCOS)不孕患者中的表达情况及临床意义。方法:选取2021年1月—2023年1月新乡医学院第一附属医院收治的87例接受IVF-ET的PCOS不孕患者作为观察组,选取同期接受健康体检的87名健康女性作为对照组。将观察组中患者根据妊娠结局分为妊娠成功组和妊娠失败组,采用微粒子化学发光免疫法检测受试者性激素指标[卵泡刺激素(FSH)、泌乳素(PRL)、孕激素(P)、雌二醇(E_(2))、黄体生成素(LH)及睾酮(T)]水平,收集患者临床基线资料,分析性激素指标与接受IVF-ET的PCOS不孕患者妊娠结局的关系。结果:观察组PRL、P、E_(2)、LH、T水平明显高于对照组,而FSH水平明显低于对照组,差异有统计学意义(t=3.138、6.261、5.723、20.071、20.363、13.584,P<0.05);87例PCOS不孕患者接受IVF-ET后,46例患者妊娠成功,41例患者妊娠失败,妊娠成功率为52.87%;妊娠成功组BMI、PRL、E_(2)、LH、T水平明显低于妊娠失败组,差异有统计学意义(t=4.649、3.388、3.837、3.735、4.192,P<0.05);logistic回归分析结果显示,BMI、PRL、E_(2)、LH、T均是影响PCOS不孕患者IVF-ET妊娠结局的独立影响因素(OR=2.232、1.083、1.020、1.310、12.759,P<0.05);绘制受试者工作曲线(ROC),PRL、E_(2)、LH、T预测曲线下面积(AUC=0.729、0.710、0.744、0.734),具有一定的预测价值,且联合预测价值更高(AUC=0.865)。结论:性激素指标在PCOS不孕患者中均呈异常表达,其中PRL、E_(2)、LH、T是接受IVF-ET的PCOS不孕患者妊娠成功的影响因素,可有效预测妊娠结局。Objective To investigate the expression and clinical significance of sex hormone indicators in infertile patients with polycystic ovary syndrome(PCOS)who received in vitro fertilization and embryotransfer(IVF-ET).Methods:87 PCOS infertile patients who received IVF-ET from hospitals from January 2021 to January 2023 were as the study subjects.They were recorded as the observation group,and 87 healthy women who underwent health examinations during the same period were selected as the control group.Patients in the observation group were divided into a successful pregnancy group and a failed pregnancy group based on pregnancy outcomes.The levels of six sex hormone indicators[follicle stimulating hormone(FSH),prolactin(PRL),progestogen(P),estradiol(E_(2)),luteinizing hormone(LH)and testosterone(T)]of the subjects were detected by microparticle chemiluminescence immunoassay.The clinical baseline data of the patients were collected,and the relationship between sex stimulating hormone indicators and pregnancy outcomes of PCOS infertility patients receiving IVF-ET was analyzed.Results:The levels of PRL,P,E_(2),LH,and T in the observation group were significantly higher than those in the control group(t=3.138,6.261,5.723,20.071,20.363,13.584;P<0.05).After receiving IVF-ET,46 out of 87 infertile patients with PCOS had successful pregnancies and 41 failed,with a success rate of 52.87%.The results of logistic regression analysis showed that BMI,PRL,E_(2),LH and T were the influencing factors for pregnancy success in PCOS infertile patients receiving IVF-ET(OR=2.232,1.083,1.020,1.310,12.759;P<0.05).The receiver operating curve(ROC)was drawn,and the results showed that the area under the PRL,E_(2),LH and T predictive curves(AUC=0.729,0.710,0.744,0.734)had certain predictive value,and the joint predictive value was higher(AUC=0.865).Conclusion:Six sex hormone indicators are abnormally expressed in PCOS infertility patients,among which PRL,E_(2),LH and T are influencing factors for pregnancy success in PCOS infertility patients r

关 键 词：多囊卵巢综合征 不孕症 体外受精-胚胎移植 性激素指标 

分 类 号：R711.6[医药卫生—妇产科学]