瑞马唑仑复合丙泊酚静脉麻醉在老年患者无痛结肠镜检查中的应用  

Application of Remimazolam Combined Propofol in Elderly Patients Undergoing Analgesia Colonoscopy

作　　者：孙瑞坤 高百成 Sun Ruikun;Gao Baicheng(Department of Anesthesiology,Zhaoyuan People’s Hospital,Zhaoyuan,Shandong,265400,China)

机构地区：[1]山东省招远市人民医院麻醉科,山东招远265400

出　　处：《黑龙江医学》2024年第20期2452-2454,共3页Heilongjiang Medical Journal

摘　　要：目的:探讨瑞马唑仑复合丙泊酚静脉麻醉在老年患者无痛结肠镜检查中的应用效果。方法:选取2023年4月—2023年6月招远市人民医院行结肠镜检查的120例老年患者作为研究对象,随机将其分为瑞马唑仑复合丙泊酚组(RP组)和丙泊酚组(P组),每组各60例。RP组采用瑞马唑仑5 mg+丙泊酚0.5 mg/kg,P组采用丙泊酚1.0 mg/kg进行麻醉。监测记录用药前5 min(T_(0))、用药后进镜前(T_(1))、进镜过肝区时(T_(2))、清醒时(T_(3))4个不同时点患者的平均动脉压(MAP)、心率(HR)。比较两组患者检结肠镜检查时间、清醒时间及患者体动、注射痛、呼吸抑制、呃逆、恶心呕吐等不良反应的发生情况。结果:所有病例均成功完成检查,且两组患者一般资料、结肠镜检查时间、苏醒时间及T_(0)时点的MAP比较,差异无统计学意义(P>0.05);T_(1)、T_(2)时点MAP均较T_(0)时点明显降低,其中RP组的降低幅度小于P组,差异有统计学意义(P<0.05);T_(3)时点两组患者的MAP均恢复至T_(0)水平,差异无统计学意义(P>0.05);RP组注射痛、呼吸抑制发生率明显低于P组,差异有统计学意义(P<0.05);RP组呃逆发生率明显高于P组,差异有统计学意义(P<0.05);体动、恶心呕吐等不良反应的发生率两组比较,差异无统计学意义(P>0.05)。结论:瑞马唑仑复合丙泊酚静脉麻醉对呼吸、循环抑制作用较小,不良反应发生率低,可安全用于老年患者结肠镜检查。Objective:To explore the efficacy of intravenous anesthesia with remimazolam combined propofol in elderly patients undergoing colonoscopy.Methods:A total of 120 elderly patients undergoing sedative colonoscopy were randomized into two groups:Group RP(remimazolam combined propofol)and Group P(propofol),with 60 patients in each group.RP group received remazolam 5 mg+propofol 0.5 mg/kg,and P group received propofol 1.0 mg/kg.MAP and HR of patients were monitored and recorded at 4 different time points:5 min before medication(T_(0)),before admission after medication(T_(1)),admission through liver area(T_(2)),and being awake(T_(3)).The colonoscopy time,waking time and adverse reactions,such as body movement,injection pain,respiratory depression,hiccup,nausea and vomiting,were compared between the two groups.Results:All cases completed the examination successfully,and there was no significant difference in the general information,colonoscopy time,recovery time and MAP of T_(0)time point between the two groups(P>0.05).MAP at T_(1)and T_(2)was significantly lower than that at T_(0),and the decrease in RP group was smaller than that in P group,the difference was statistically significant(P<0.05).At T_(3)time point,MAP of both groups recovered to T_(0)level,with no statistically significant difference(P>0.05).The incidence of injection pain and respiratory depression in RP group was significantly lower than that in P group,with statistically significant difference(P<0.05).The incidence of hiccup was significantly higher than that of group P,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of body movement,nausea and vomiting between the two groups(P>0.05).Conclusion:RP may have non-inferior efficacy and a higher safety profile than propofol in elderly outpatients undergoing colonoscopy,so RP may be more suitable for elderly patients undergoing colonoscopy.

关 键 词：苯磺酸瑞马唑仑 丙泊酚 老年患者 无痛肠镜 

分 类 号：R614[医药卫生—麻醉学]