急性肾损伤与新型布尼亚病毒感染者死亡的关系研究  

Study on the relationship between acute kidney injury and death of patients infected with novel bunyavirus

作　　者：臧传飞 于美言 牛铁明[2] Zang Chuanfei;Yu Meiyan;Niu Tieming(Department of Nephrology,Weihai Central Hospital Affiliated to Qingdao University,Weihai 264400,China;Department of Nephrology,Shenyang Red Cross Hospital,Shenyang 110013,China)

机构地区：[1]青岛大学附属威海市中心医院肾内科,山东威海264400 [2]沈阳市红十字会医院肾内科,辽宁沈阳110013

出　　处：《实用药物与临床》2024年第10期727-731,共5页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨急性肾损伤(AKI)与新型布尼亚病毒感染者死亡的关系并分析其危险因素。方法回顾性分析2016年5月至2023年10月于威海市中心医院住院治疗的新型布尼亚病毒感染者135例,按照患者是否发生AKI分成AKI组(n=37)和无AKI组(n=98),比较两组性别、年龄、病毒载量、基础疾病、应用利巴韦林情况、病程、实验室检查、是否合并多脏器衰竭及死亡率等。ROC曲线分析相关指标对新型布尼亚病毒感染者并发AKI的预测价值。结果AKI组的死亡率高于无AKI组(P<0.01),发生AKI是新型布尼亚病毒感染者死亡的危险因素。有高血压、年龄≥60岁、病毒载量>104(拷贝/ml)、血小板计数<30×10^(9)/L、基础肌酐值>80μmol/L、基础eGFR值<60 ml/(min·1.73m^(2))是新型布尼亚病毒感染者出现AKI的危险因素。结论我院新型布尼亚病毒感染者病情较重,死亡比例高,发生AKI是其危险因素。高血压、年龄、病毒载量、血小板计数、基础肌酐值、基础eGFR对新型布尼亚病毒感染者出现AKI有预警作用。Objective To investigate the relationship between acute kidney injury(AKI)and death of patients infected with novel bunyavirus,and analyze its risk factors.Methods A retrospective analysis was conducted on 135 patients with the novel bunyavirus who were hospitalized at Weihai Central Hospital from May 2016 to October 2023.The patients were divided into anAKI group(n=37)and a no-AKI group(n=98)based on whether they experienced acute kidney injury.The two groups were compared in terms of gender,age,viral load,underlying diseases,use of ribavirin,disease course,laboratory tests,presence of multiple organ failure,and mortality rate.The predictive value of related indicators for novel bunyavirus complicated with AKI was analyzed by ROC curve.Results The mortality rate of AKI group was higher than that of no-AKI group(P<0.01),and the occurrence of AKI was a risk factor for the death of patients infected with novel bunyavirus.Hypertension,age≥60 years,viral load>104(copies/ml),platelet count<30×10^(9)/L,baseline creatinine value>80μmol/L,and baseline eGFR value<60 ml/(min·1.73m^(2))were risk factors for occurrence of AKI in patients infected with novel bunyavirus.Conclusion The condition of patients infected with novel bunyavirus in our hospital is severe and with a high mortality rate,and the occurrence of AKI is a risk factor.Hypertension,age,viral load,platelet count,baseline creatinine level,and baseline eGFR have warning effects on the occurrence of AKI in patients infected with novel bunyavirus.

关 键 词：急性肾损伤 血小板减少 新型布尼亚病毒 死亡 

分 类 号：R692[医药卫生—泌尿科学] R511[医药卫生—外科学]