基于“肝心和合”理论的动脉粥样硬化性疾病病机演变  

Pathogenesis Evolution of Atherosclerotic Diseases Based on Theory of“Harmony Between Liver and Heart”

作　　者：张颖[1] 王华文[1] 于游 张欢[1] 段盈竹 郭鹤[1] 梁健 左欣蕾 于睿[1] ZHANG Ying;WANG Huawen;YU You;ZHANG Huan;DUAN Yingzhu;GUO He;LIANG Jian;ZUO Xinlei;YU Rui(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《辽宁中医杂志》2024年第10期4-8,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82274494);国家中医药管理局中医药古籍文献和特色技术传承专项项目(GZY-KJS-2020-026);辽宁省科技厅(软科学研究计划)项目(2023040055-JH4/107);辽宁省教育厅面上项目(LJKMZ20221310);辽宁省科技厅博士科研启动基金项目(2022-BS-205);辽宁省科技厅应用基础研究计划项目(2023JH2/101600030);辽宁中医药大学青年项目(2021LZY022)。

摘　　要：动脉粥样硬化性疾病对人类的生命和健康造成了威胁,在生物-心理-社会医学的模式下,基于中医古籍挖掘与整理,结合现代医学理论及实验进展,以中医基础理论为指导,提出基于“肝心和合”理论的AS性疾病病机演变全过程,即预病状态→已病状态→病复状态。系统阐释在AS性疾病中“心”与“肝”状态失衡是导致疾病进展或骤变的主要因素,“郁-痰-瘀-毒-虚”的病理特点,并逐一对病理特点进行中西医的发病机制诠释,五者在疾病中不仅可以单一存在,而且可以相互兼见,相互作用,相互影响,其中是“郁”是“痰-瘀-毒-虚”进一步病变的基础。以肝郁心虚、心脉遏滞;肝心失司、心脉瘀阻;肝心失和、瘀毒虚互结等中医内涵揭示AS性疾病的发病机制,为中西医结合诊疗提供新思路和新方法。Atherosclerotic diseases(AS)pose a threat to human life and health.Under the model of bio-psycho-social medical model,based on the mining and collation of ancient Chinese medical books,combined with modern medical theory and experimental progress and guided by the basic theory of traditional Chinese medicine,the whole process of pathogenesis evolution of AS based on the theory of“harmony between liver and heart”is proposed,that is,pre disease state→sick state→recovery state.The system explains that the imbalance between“heart”and“liver”states in AS diseases is the main factor leading to disease progression or sudden changes.The pathological characteristics of“depression-phlegm-stasis-toxin-deficiency”are explained,and the pathogenesis of traditional Chinese and Western medicine is explained one by one.The five can not only exist alone in the disease,but also coexist,interact and influence each other.Among them,“depression”is the basis for further pathological changes in“phlegm-stasis-toxin-deficiency”.The traditional Chinese medicine connotations,including liver depression and heart deficiency,heart meridian obstruction;dysfunction of liver and heart and blood stasis obstructing heart meridian;disharmony between liver and heart and the combination of blood stasis,toxin and deficiency,reveal the pathogenesis of AS diseases so as to provide new ideas and methods for the integrated diagnosis and treatment of traditional Chinese and Western medicine.

关 键 词：肝心和合 动脉粥样硬化 病因病机 

分 类 号：R256[医药卫生—中医内科学]