健脾通络方改善胃癌术后失眠临床疗效观察  

Clinical Observation on Jianpi Tongluo Recipe(健脾通络方)Improving Postoperative Insomnia of Gastric Cancer

作　　者：刘怡[1] 任建琳[1] 袁晨越 储金砚 周霖 赵勇 LIU Yi;REN Jianlin;YUAN Chenyue;CHU Jinyan;ZHOU Lin;ZHAO Yong(Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《辽宁中医杂志》2024年第10期80-84,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82174452);上海市科技创新行动计划生物医药科技支撑专项(22S21901000);上海医学创新发展基金会“未来计划”中医药传承人才培育-院级名中医项目(WLJH2021ZY-MZY026)。

摘　　要：目的观察健脾通络方治疗胃癌术后失眠的临床疗效。方法将80例胃癌术后失眠患者随机分为对照组及治疗组,每组40例。对照组(40例,脱落2例)给予艾司唑仑片治疗,治疗组(40例,脱落1例)给予健脾通络方治疗,7 d为1个治疗疗程,两组均治疗4个疗程。统计两组治疗前后匹兹堡睡眠质量指数(PSQI)评分、汉密尔顿焦虑量表(HAMA)评分及中医证候评分变化,比较舌象、苔质变化,对比两组中医证候疗效,并监测不良反应事件的发生。结果两组PSQI评分比较,治疗组PSQI各项指标及总分均低于对照组(P<0.05);两组HAMA评分比较,治疗组优于对照组(P<0.05);两组中医证候评分比较,治疗组明显优于对照组(P<0.05);治疗后,治疗组舌象、苔质也较治疗前好转(P<0.05);治疗后,两组疗效相比,治疗组有效率为79.49%(31/39),对照组有效率为60.53%(23/38),差异具有统计学意义(P<0.05)。结论健脾通络方能够有效提高胃癌术后患者睡眠疗效,改善患者睡眠障碍、提高患者生活质量,且不良反应小,能为临床改善胃癌患者相关性失眠提供参考。Objective To observe the clinical effect of Jianpi Tongluo Decoction(健脾通络方)on insomnia after gastric cancer surgery.Methods Eighty patients with postoperative insomnia of gastric cancer were randomly divided into control group and treatment group,with 40 cases in each group.The control group(40 cases,2 cases of exfoliation)were treated with estazolam tablets,while the treatment group(40 cases,1 case of exfoliation)were treated with Jianpi Tongluo Decoction,with 7 days as a treatment course,and both groups were treated for 4 courses.The changes of Pittsburgh Sleep Quality Index(PSQI)score,Hamilton Anxiety Scale(HAMA)score and TCM syndrome score before and after treatment were counted,the changes of tongue picture and coating quality were compared,the curative effect of TCM syndrome in the two groups was compared,and the occurrence of adverse reaction events was monitored.Results The PSQI indexes and total scores of the treatment group were lower than those of the control group(P<0.05).The HAMA score of the treatment group was better than that of the control group(P<0.05).The score of TCM syndrome in the treatment group was significantly better than that in the control group(P<0.05).After treatment,the tongue picture and coating quality in the treatment group were also improved compared with those before treatment(P<0.05).After treatment,the effective rate of the two groups was 79.49%(31/39)in the treatment group and 60.53%(23/38)in the control group,and the difference was statistically significant(P<0.05).Conclusion Jianpi Tongluo Formula can effectively improve the sleep efficacy of patients with gastric cancer after operation,relieve the sleep disorder,improve the quality of life of patients with small side effects,and can provide a reference for clinical improvement of insomnia in patients with gastric cancer.

关 键 词：健脾通络方 胃癌 失眠 疗效观察 

分 类 号：R273[医药卫生—中西医结合]