颅骨缺损颅骨修补术后应用中药“独一味”对皮瓣下积液的疗效  

Therapeutic Effect of Duyiwei(Phlomoides rotata)on Subcutaneous Fluid Accumulation after Skull Repair Surgery for Skull Defects

作　　者：付增彬 秦立鹏 李尧 李普阳[1] 王凯 赵亚鹏[1] 高雪亮[1] FU Zengbin;QIN Lipeng;LI Yao;LI Puyang;WANG Kai;ZHAO Yapeng;GAO Xueliang(Department of Neurosurgery,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北省中医院神经外科,河北石家庄050000

出　　处：《辽宁中医杂志》2024年第10期112-115,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2019027)。

摘　　要：目的探讨颅骨缺损颅骨修补术后应用中药独一味对皮瓣下积液疗效的研究。方法该研究所有病例均来自于2019年1月—2023年9月期间医院脑外科收治符合纳入标准的颅骨修补术后合并皮瓣下积液患者共92例,根据随机数字法将所有患者分为试验组(46例)与对照组(46例)。所有颅骨修补手术均在相同手术消毒标准的手术室内进行,对照组根据皮瓣下积液情况予以对症处理,试验组在对照组的基础上予以中药独一味。对比两组临床治疗效果、血清肿瘤坏死因子-α(Serum tumor necrosis factor-α,TNF-α)、白细胞介素-8(Interleukin-8,IL-8)、降钙素原(procalcitonin,PCT)水平、生活质量、并发症反应情况。应用SPSS24.0统计进行统计分析。结果与对照组相比,试验组临床有效率较高(P<0.05)。与治疗前相比,治疗后血清TNF-α、IL-8及PCT水平降低(P<0.05);疗后与对照组相比,试验组血清TNF-α、IL-8及PCT水平较低(P<0.05)。与治疗前相比,治疗后功能领域、总体健康状况等生活质量评分升高,症状领域评分降低(P<0.05);疗后与对照组相比,试验组功能领域、总体健康状况方面生活质量评分较高,症状领域评分较低(P<0.05)。与对照组相比,试验组并发症发生率较低(P<0.05)。结论将中药独一味应用于颅骨缺损颅骨修补术后合并皮瓣下积液的治疗中,能够显著提高疗效及生活质量,副作用少,其治疗机制可能与抑制TNF-α、IL-8及PCT水平有相关性。Objective To investigate the therapeutic effect of traditional Chinese medicine Duyiwei(Phlomoides rotata)on subcutaneous fluid accumulation after skull repair surgery for skull defects.Method All cases in this study were from 92 patients admitted to the neurosurgery department of the hospital from January 2019 to September 2023 who met the inclusion criteria for skull repair surgery with subcutaneous fluid accumulation.According to the random number method,all patients were divided into an experimental group(46 cases)and a control group(46 cases).All skull repair operations were performed in the operating room with the same surgical disinfection standard.The control group was given symptomatic treatment according to the fluid accumulation under the flap,and the experimental group was given traditional Chinese medicine alone on the basis of the control group.The clinical therapeutic efficacy,the levels of serum tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),procalcitonin(PCT),quality of life and response to complications were compared between the two groups.SPSS 24.0 statistics was used for statistical analysis.Result Compared with that of the control group,the clinical effective rate of the experimental group was higher(P<0.05).Compared with those before treatment,the levels of serum TNF-α,IL-8 and PCT decreased after treatment(P<0.05).And the levels of the experimental group were relatively lower(P<0.05).Compared with those before treatment,the quality of life scores in functional areas and overall health status increased after treatment,while the symptom area scores decreased(P<0.05).After treatment,compared with the control group,the experimental group had higher quality of life scores in terms of functional areas and overall health status,while the symptom area score was lower(P<0.05).Compared with that in the control group,the incidence of complications in the experimental group was lower(P<0.05).Conclusion In the treatment of skull defect and effusion under skin flap after skull repair,the applicati

关 键 词：颅骨缺损颅骨修补术 中药独一味 皮瓣下积液 生活质量 

分 类 号：R274[医药卫生—中医骨伤科学]