养精毓麟膏联合针刺对宫腔粘连患者术后妊娠率及子宫内膜容受性的影响  

Effect of Yangjing Yulin Paste(养精毓麟膏)Combined with Acupuncture on Postoperative Pregnancy Rate and Endometrium Tolerance in Patients with Uterine Adhesion

作　　者：李惠 冯婷 赵燕燕 刘玉洁 柯妍 LI Hui;FENG Ting;ZHAO Yanyan;LIU Yujie;KE Yan(Department of Gynecology,Shenzhen Integrated Traditional Chinese and Western Medicine Hospital,Shenzhen 518000,Guangdong,China)

机构地区：[1]深圳市中西医结合医院妇科,广东深圳518000

出　　处：《辽宁中医杂志》2024年第10期159-162,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：广东省名中医传承工作室项目(粤中医办函[2019]5号);深圳市“医疗卫生三名工程”资助项目(SZZYSM202106003);深圳市宝安区中医药发展基金会资助项目(2020KJCX-KTYJ-161)。

摘　　要：目的探讨养精毓麟膏联合针刺对宫腔粘连(IUA)患者术后妊娠率及子宫内膜容受性的影响。方法将2020年12月—2022年12月接受宫腔镜下粘连分离术治疗的86例UIA患者随机分为对照组与试验组各43例,前者予戊酸雌二醇、拜阿司匹林、地屈孕酮治疗;试验组予养精毓麟膏、针刺治疗,两组均连续治疗3个月经周期。观察两组子宫内膜情况(子宫内膜厚度、子宫内膜容积)、子宫动脉血流参数[子宫动脉血流阻力指数(RI)、子宫动脉搏动指数(PI)]、子宫内膜血流参数[血流指数(FI)、血管化指数(VI)、血管化血流指数(VFI)]的变化情况。随访妊娠结局。结果治疗3个月经周期后,试验组子宫内膜厚度显著高于对照组(t=10.458,P=0.000),子宫内膜容积比较无统计学意义(t=1.659,P=0.113);试验组子宫动脉血流参数RI、PI均显著低于对照组(t=4.295、10.856,P=0.000、0.000);试验组子宫内膜血流参数VI、FI、VFI均显著高于对照组(t=14.307、5.589、8.366,P=0.000、0.000、0.000);随访后,两组受孕人数比较差异无统计学意义(χ^(2)=0.205,P=0.651),但试验组妊娠成功率高于对照组(χ^(2)=4.821,P=0.028)。结论养精毓麟膏联合针刺能够可以有效改善IUA患者术后子宫内膜容受性,提高术后妊娠成功率,值得临床借鉴。Objective To investigate the effects of Yangjing Yulin Paste(养精毓麟膏)combined with acupuncture on postoperative pregnancy rate and endometrial tolerance in patients with intrauterine adhesion(IUA).Methods From December 2020 to December 2022,86 patients with UIA who received hysteroscopy adhesion dissociation were randomly divided into control group(43 cases)and experimental group(43 cases).The former was treated with estradiol valerate,aspirin and dydrogesterone.The experimental group was treated with Yangjing Yulin Paste and acupuncture,and the two groups were treated for 3 consecutive menstrual cycles.The changes of endometrial conditions(endometrial thickness,endometrial volume),uterine artery blood flow parameters[uterine artery flow resistance index(RI),uterine artery pulsation index(PI)],and endometrial blood flow parameters[blood flow index(FI),vascularization index(VI),vascularization blood flow index(VFI)]in the two groups were observed.The pregnancy outcome was followed up.Results After 3 menstrual cycles,the endometrial thickness of the experimental group was significantly higher than that of the control group(t=10.458,P=0.000),but there was no statistical significance in endometrial volume(t=1.659,P=0.113).The uterine artery blood flow parameters(RI and PI)in the experimental group were significantly lower than those in the control group(t=4.295,10.856,P=0.000,0.000).Endometrial blood flow parameters(VI,FI and VFI)in the experimental group were significantly higher than those in the control group(t=14.307,5.589,8.366,P=0.000,0.000).After follow-up,there was no significant difference in the number of pregnancies between the two groups(χ^(2)=0.205,P=0.651),but the pregnancy success rate of the experimental group was higher than that of the control group(χ^(2)=4.821,P=0.028).Conclusion Yangjing Yulin Paste combined with acupuncture can effectively improve postoperative endometrial receptivity and improve the success rate of pregnancy in patients with IUA,which is worthy of clinical reference.

关 键 词：宫腔粘连术后 养精毓麟膏 针刺 妊娠率 子宫内膜容受性 

分 类 号：R246.3[医药卫生—针灸推拿学]