天蚕素A及其衍生物生物活性的研究现状  

Research status on bioactivity of Cecropin A and its derivatives

作　　者：晁镜茹 苏春丽 莫金秋 李春苗 李欣 廖洪利[1] CHAO Jing-ru;SU Chun-li;MO Jin-qiu;LI Chun-miao;LI Xin;LIAO Hong-li(College of Pharmacy,Chengdu Medical College,Chengdu 610500,SichuanProvince,China;School of Public Health,Chengdu Medical College,Chengdu 610500,SichuanProvince,China;College of Medicine,Tarim University,Alar&43300,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]成都医学院药学院,四川成都610500 [2]成都医学院公共卫生学院,四川成都610500 [3]塔里木大学医学院,新疆维吾尔自治区阿拉尔843300

出　　处：《中国临床药理学杂志》2024年第19期2905-2908,共4页The Chinese Journal of Clinical Pharmacology

基　　金：四川省中央引导地方科技发展基金资助项目(2023ZYD0062);塔里木大学校长基金自然科学基金资助项目(TDZKSS202318)。

摘　　要：近年来,天然抗菌肽成为新型抗生素开发的一个重要方向。天蚕素具有抗菌谱广、耐受性好、低药物不良反应等特点。天蚕素A作为天蚕素家族中第1个被发现的抗菌肽,具有多种重要的生物活性。该文通过查阅相关文献资料,对近年来天蚕素A及其衍生物在抗细菌、抗真菌、抗寄生虫、抗肿瘤等生物活性方面的研究进行综述,展望了其应用前景,以期为天蚕素的进一步研究和开发提供参考依据。In recent years,natural antimicrobial peptides have become an important direction in the development of novel antibiotics.Cecropin has the characteristics of wide antibacterial spectrum,good tolerance and low adverse drug reactions.As the first antimicrobial peptide discovered in the family of Cecropin,Cecropin A has many important biological activities.In this paper,the research on the antibacterial,antifungal,antiparasitic and antitumor activities of Cecropin A and its derivatives in recent years was reviewed,and its application prospect was prospected,in order to provide reference for further research and development of cecropin.

关 键 词：天蚕素A 抗菌 抗真菌 抗寄生虫 抗肿瘤 

分 类 号：R28[医药卫生—中药学]