贵州苗族孕妇膳食炎症指数与妊娠期糖尿病发生风险的队列研究  

A cohort study on the dietary inflammatory index of Miao pregnant women in Guizhou and the risk of gestational diabetes mellitus

作　　者：王芳 倪晓绒 王榕 乔田 魏绍峰[1] 梁一[1,2] WANG Fang;NI Xiao-rong;WANG Rong;QIAO Tian;WEI Shao-feng;LIANG Yi(School of Public Health and Health,Guizhou Medical University,Key Laboratory of Environmental Pollution and Disease Monitoring,Ministry of Education,Guizhou,Guiyang 561113,China;不详)

机构地区：[1]贵州医科大学公共卫生与健康学院,环境污染与疾病监控教育部重点实验室,贵州贵阳561113 [2]贵州医科大学附属医院临床营养科,贵州贵阳550004

出　　处：《现代预防医学》2024年第19期3523-3528,共6页Modern Preventive Medicine

基　　金：国家自然科学基金(82160616);贵州医科大学附属医院博士科研启动基金(gyfybsky-2021-22)。

摘　　要：目的 探讨贵州地区苗族单胎孕妇孕前一年、孕早期和两个时期平均膳食炎症指数(DII)水平与妊娠期糖尿病(GDM)发生风险的关联。方法 采用前瞻性队列研究,选取2022年6月-2023年3月在贵州省黔东南苗族侗族自治州队列中心进行常规产检的苗族单胎孕妇作为研究对象,使用食物频率问卷(FFQ)收集膳食信息,根据膳食信息计算孕前一年和孕早期的DII水平,两个时期取均值为平均DII水平。于孕24~28周进行75克葡萄糖耐量试验(OGTT),判定孕妇是否患GDM。按三分位数法将各个时期的DII水平由低到高分为三组(Q1~Q3)。Logistic回归分析孕前一年、孕早期和两个时期平均DII水平与GDM发生风险的关联。结果 孕前一年和两个时期平均DII水平三分位数最高组GDM发生风险分别是最低组的2倍(OR=2.000,95%CI:1.269~3.152)和1.506倍(OR=1.506,95%CI:1.040~2.182)。结论较高的孕前一年和两个时期平均DII水平可能与GDM发生风险增加有关,提示备孕及孕期减少促炎饮食的摄入可能有助于降低GDM发病率。Objective To explore the association between the average dietary inflammatory index(DIl)levels in the year prior to pregnancy and early pregnancy,as well as the risk of gestational diabetes mellitus(GDM)among Miao women with single-ton pregnancies in Guizhou.Methods A prospective cohort study was conducted,selecting Miao women with singleton preg-nancies who underwent routine prenatal examinations at the cohort center in Qiandongnan Miao and Dong Autonomous Pre-fecture from June 2022 to March 2023.Dietary information was collected using a food frequency questionnaire(FFQ),and the DI levels for the year prior to pregnancy and early pregnancy were calculated.The average DII level was derived from both periods.A 75g oral glucose tolerance test(OGTT)was performed between 24 to 28 weeks of gestation to determine the pres-ence of GDM.DII levels for each period were categorized into three groups(Q1 to Q3)based on quartiles.Logistic regression analysis was employed to assess the association between the average DIl levels for the year prior to pregnancy,early preg-nancy,and the risk of GDM.Results The highest quartile of average DII levels for the year prior to pregnancy and both peri-ods had a GDM risk that was 2 times(OR=2.000,95%CI:1.269-3.152)and 1.506 times(0R=1.506,95%CI:1.040-2.182)higher,respectively,compared to the lowest quartile.Conclusion Higher average DII levels in the year prior to pregnancy and during both periods may be associated with an increased risk of GDM,suggesting that reducing pro-inflammatory dietary intake during preconception and pregnancy may help lower the incidence of GDM.

关 键 词：苗族孕妇 膳食炎症指数 妊娠期糖尿病 前瞻性研究 

分 类 号：R714.256[医药卫生—妇产科学] R151.41[医药卫生—临床医学]