纳米疫苗载体材料的研究进展  

Research progress in nano-vaccine carrier materials

作　　者：尚金梦 赵静(综述)[1] 常亮[1] 翟丽丽(审校) SHANG Jinmeng;ZHAO Jing;CHANG Liang;ZHAI Lili(NCPC New Drug Research and Development Co.,Ltd.,State Key Laboratory of Antibody Research&Development,Shijiazhuang 052165,Hebei Province,China)

机构地区：[1]华北制药集团新药研究开发有限责任公司抗体药物研制国家重点实验室,河北石家庄052165

出　　处：《中国生物制品学杂志》2024年第9期1140-1145,1151,共7页Chinese Journal of Biologicals

基　　金：河北省重点研发计划(21372403D)。

摘　　要：疫苗是一种预防传染病和治疗疾病的重要手段。近年,有研究采用分子生物学方法将病原体的多肽蛋白或核酸整合至载体上,构建新型疫苗。其中纳米材料具有生物相容性高、毒性低、抗原装载效率高、靶向性强等优势,已成为纳米疫苗制备中的常用载体。目前,用于制备纳米疫苗的载体材料包括蛋白质/肽、脂质体、聚合物和无机物等,可用于多种疾病相关纳米疫苗的研发及制备。本文就各种纳米疫苗的优势及纳米疫苗载体材料的研究进展作一综述,以期为纳米疫苗的设计、研发及应用提供新的思路和策略。Vaccine is an important means to prevent infectious diseases and treat diseases.In recent years,molecular biological methods have been used to integrate polypeptide proteins or nucleic acids of pathogens into vectors to construct new vaccines.Among them,nano-materials have the advantages of high biocompatibility,low toxicity,high antigen loading efficiency and strong targeting,and have become commonly used carriers in the preparation of nano-vaccines.At present,the carrier materials for nano-vaccines include proteins/peptides,liposomes,polymers and inorganic substances,which can be used for the development and preparation of nano-vaccines related to various diseases.In this paper,the advantages of various nano-vaccines and the research progress in nano-vaccine carrier materials have been reviewed,so as to provide new ideas and strategies for the design,development and application of nano-vaccines.

关 键 词：纳米疫苗 载体 蛋白质 脂质体 聚合物 无机物 

分 类 号：R392[医药卫生—免疫学]