梅花针叩刺联合他扎罗汀、咪喹莫特乳膏治疗多发性跖疣的疗效观察  

The clinical observation on the treatment of multiple plantar warts with plum-blossom needling combined with tazarotene cream and imiquimod cream

作　　者：李凤春 许教雄[2] 何仁亮 李辉 严丽娟 马玉楠 LI Fengchun;XU Jiaoxiong;HE Renliang;LI Hui;YAN Lijuan;MA Yunan(Third People′s Hosiptal of Zhuhai,Zhuhai 519001,China;Huangpu People′s Hospital of Zhongshan,Zhongshan 528429,China;Dermatology Hospital,Southern Medical University,Guangzhou 510091,China;Department of Epidemiology,School of Public Health,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]珠海市第三人民医院,广东珠海519001 [2]中山市黄圃人民医院,广东中山528429 [3]南方医科大学皮肤病医院,广东广州510091 [4]南方医科大学公共卫生学院流行病学系,广东广州510515

出　　处：《皮肤性病诊疗学杂志》2024年第9期595-601,共7页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的观察梅花针叩刺联合他扎罗汀、咪喹莫特乳膏外用治疗多发性跖疣的疗效。方法将60例多发性跖疣患者随机分为观察组、对照1组与对照2组,每组20例。3组患者采用手术刀片削薄疣体及周围增厚的角质后,观察组采用梅花针叩刺联合外用他扎罗汀、咪喹莫特乳膏治疗,对照1组采用CO_(2)点阵激光联合外用他扎罗汀、咪喹莫特乳膏治疗,对照2组仅单纯外用他扎罗汀、咪喹莫特乳膏治疗。梅花针和CO_(2)点阵激光每隔10 d治疗1次,最多治疗9次。所有患者均治疗3个月,治疗期间观察不良反应,治疗结束后比较3组临床疗效。对痊愈的患者进行3个月的随访,观察复发情况。结果治疗结束后观察组痊愈率为94.44%,对照1组为88.24%,对照2组为45.00%。三组患者的痊愈率差异具有统计学意义(χ^(2)=14.63,P<0.05)。观察组与对照1组比较,痊愈率(Z=-0.61)、治疗次数(Z=-0.37)、治疗时间(Z=-0.36)均相当(P均>0.0167),但与对照2组相比,观察组痊愈率更高(Z=-3.23)、治疗次数更少(Z=-2.57),治疗时间更短(Z=-2.59),均P<0.0167。3组复发率差异无统计学意义。三组患者在治疗期间均无严重不良反应。结论梅花针叩刺联合他扎罗汀、咪喹莫特乳膏外用治疗多发性跖疣,临床疗效与点阵激光联合他扎罗汀、咪喹莫特乳膏外用相当,优于单纯外用他扎罗汀、咪喹莫特乳膏,操作简单,可作为多发性跖疣简便优秀的治疗方法。Objective To observe the efficacy of plum-blossom needling combined with tazarotene cream and imiquimod cream in the treatment of multiple plantar warts.Methods Sixty patients with multiple plantar warts were randomly divided into the observation group,control groups 1 and 2,20 cases per group.After removal part of warts and thickened stratum corneum with scalpel,the observation group was treated with plum-blossom needling in combination with tazarotene cream and imiquimod cream.And the control group 1 was treated with fractional CO_(2) laser in combination with tazarotene cream and imiquimod cream,while the control group 2 was treated with tazarotene cream and imiquimod cream alone.Plum-blossom needling and fractional CO_(2) laser were given once every 10 days for a total of no more than 9 times.All patients were treated for 3 months and adverse reactions were observed during the follow-up period.The clinical efficacy was compared among three groups.The recurrence rates were observed during a 3-month follow-up after the treatment.Results The cure rates in observation group,and control groups 1 and 2 were 94.44%,88.24%and 45.0%,respectively(χ^(2)=14.63,P<0.05).However,there were no significant differences in cure rate,total number of treatment and the duration of treatment between the observation and control group 1(cure rate:Z=-0.61,P>0.0167,total number of the treatment:Z=-0.37,P>0.0167,the duration of the treatment:Z=-0.36,P>0.0167).In contrast,the observation group had higher cure rate(Z=-3.23,P<0.0167),fewer treatments(Z=-2.57,P<0.0167)and shorter treatment duration(Z=-2.59,P<0.0167)in comparison to the control group 2.The recurrence rates were comparable among the three groups.No severe adverse reactions were observed in any groups during the treatment.Conclusions Plum-blossom needling combined with tazarotene cream and imiquimod cream displays a comparable efficacy to fractional CO_(2) laser in combination with tazarotene cream and imiquimod cream,but superior to tazarotene cream and imiquimod cream alone

关 键 词：多发性跖疣 梅花针 点阵激光 他扎罗汀 咪喹莫特 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]