盐酸奥洛他定与枸地氯雷他定治疗慢性荨麻疹的比较分析  

Comparison of the efficacy between olopatadine hydrochloride and desloratadine citrate disodium for chronic urticaria

作　　者：吴丹丹 付旭晖 赵军磊 王哲新 WU Dandan;FU Xuhui;ZHAO Junlei;WANG Zhexin(Kaifeng People′s Hospital,Kaifeng 475000,China)

机构地区：[1]开封市人民医院,河南开封475000

出　　处：《皮肤性病诊疗学杂志》2024年第9期613-618,共6页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：河南省医学科技攻关计划项目(LHGJ20210831)。

摘　　要：目的对比分析盐酸奥洛他定与枸地氯雷他定治疗慢性荨麻疹的疗效。方法选取开封市人民医院皮肤科2020年10月—2024年1月收治的184例慢性荨麻疹患者,随机分为两组。实验组92例,使用盐酸奥洛他定治疗;对照组92例,使用枸地氯雷他定治疗。均连续治疗1个月。观察两组患者治疗后的临床有效率、治疗前后症状积分、皮肤病生活质量指数调查表(DLQI)得分、荨麻疹控制程度(UCT)评分及不良反应发生情况。结果治疗1个月后,实验组的临床总有效率为95.65%,对照组的临床总有效率为86.96%,两组比较差异有统计学意义(χ^(2)=4.38,P=0.036);实验组风团数量、风团大小、瘙痒程度积分分别为1.02±0.16、0.88±0.18、0.88±0.21,低于对照组的1.13±0.24、0.96±0.13、0.97±0.25(均P<0.01);实验组的DLQI、UCT评分分别为4.67±1.02、12.01±1.89,对照组的DLQI、UCT评分分别为5.11±1.11、10.98±2.41,两组比较差异有统计学意义(均P<0.01)。两组不良反应发生率比较差异无统计学意义(P=1.000)。结论盐酸奥洛他定与枸地氯雷他定治疗慢性荨麻疹的安全性均较好,但盐酸奥洛他定的疗效更佳,更易于控制荨麻疹程度,可明显改善患者临床症状及生活质量。Objective To compare the efficacy of olopatadine hydrochloride and desloratadine citrate disodium for the treatment of chronic urticaria.Methods A total of 184 patients with chronic urticaria were enrolled at the department of dermatology of Kaifeng People′s Hospital from October 2020 to January 2024,and were randomly assigned into the study group(92 cases,olopatadine hydrochloride)and the controls(92 cases,desloratadine citrate disodium).Following one-month treatment,the clinical effective rate,symptom score,dermatology life quality index(DLQI)score and urticaria control test(UCT)score before and after the treatment,and adverse reactions were evaluated in both groups.Results After 1-month treatment,the total clinical effective rates were significantly higher in the study group than in the controls(95.65%vs.86.96%,χ^(2)=4.38,P=0.036).Moreover,the number and size of skin lesion,and itching severity were markedly lower in the study group(1.02±0.16 vs.1.13±0.24 for lesion number;0.88±0.18 vs.0.96±0.13 for lesion size,and 0.88±0.21 vs.0.97±0.25 for itching severity,P<0.01 for all).The DLQI score and UCT score also differed significantly between these two treatments(4.67±1.02 vs.5.11±1.11 for DLQI and 12.01±1.89 vs.10.98±2.41 for UCT,P<0.01 for both).The incidence rates of adverse reactions were similar between these two groups(4.35%vs.5.43%).Conclusion Although both desloratadine citrate disodium and olopatadine hydrochloride are safe for chronic urticaria,olopatadine hydrochloride is more effective.

关 键 词：盐酸奥洛他定 枸地氯雷他定 慢性荨麻疹 生活质量 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]