特应性皮炎治疗的新进展  

New advances in the treatment of atopic dermatitis

作　　者：王欣钰 张国惠 WANG Xinyu;ZHANG Guohui(Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010000

出　　处：《皮肤性病诊疗学杂志》2024年第9期643-651,共9页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：特应性皮炎(AD)是一种与遗传过敏素质有关的慢性、复发性、炎症性、瘙痒性皮肤病。传统治疗以修复皮肤屏障、外用糖皮质激素及钙调磷酸酶抑制剂、系统治疗、光疗等为主,通常难以达到临床治愈,故有一定局限性。近年来基于AD的病因与发病机制研究,生物制剂和小分子靶向药物已应用于AD的临床治疗,但因价格昂贵而受众面小,故学者亦在尝试探索其他治疗方法如中药提取物、变应原免疫治疗和微生态调节等。本文综述AD治疗的新进展。Atopic dermatitis(AD)is a chronic,recurrent,inflammatory and pruritic skin disease related to genetic allergic predisposition.Traditional treatments mainly include repairing the skin barrier,using topical glucocorticoids and calcineurin inhibitors,systemic therapy and phototherapy.But there are certain limitations because of the difficulty to achieve clinical cure.In recent years,based on the etiology and pathogenesis of AD,biologics and small molecule targeted drugs have been used in the clinical treatment.However,the high cost limits their wide use in clinic.Therefore,some scholars are also attempting to explore other therapeutic regimens such as extracts of traditional Chinese medicinal herbs,allergen immunotherapy,and regulation of microbial homeostasis.Here we review the advances in the treatment of AD.

关 键 词：特应性皮炎 生物制剂 小分子靶向药物 中药提取物 变应原免疫治疗 微生态调节 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]