篮状菌属次级代谢产物结构及活性的研究进展  

Research progress on the structure and activity of secondary metabolites of Talaromyces sp.

作　　者：安婷 谭慧 郭蓉 马晓丽 文怀秀[1] An Ting;Tan Hui;Guo Rong;Ma Xiaoi;Wen Huaixiu(Key Laboratory of Tibetan Medicine Research,Northwest Institute of Plateau Biology,Chinese Academy of Sciences/Qinghai Provincial Key Laboratory of Tibetan Medicine Research,Xining 810008;University of Chinese Academy of Sciences,Beijing 100049)

机构地区：[1]中国科学院西北高原生物研究所青海省藏药研究重点实验室,西宁810008 [2]中国科学院大学,北京100049

出　　处：《中国抗生素杂志》2024年第9期961-985,共25页Chinese Journal of Antibiotics

基　　金：青海省自然科学基金面上项目(No.2023-ZJ-927M)。

摘　　要：内生真菌的次级代谢产物是近年天然产物的研究热点。篮状菌属(Talaromycessp.)是一种重要的内生真菌,是青霉属(Penicillium)的有性型属菌种。Talaromyces sp.属分布广泛,其次级代谢产物包括生物碱类、多肽类、酯类和聚酮类等,其中一些具有抑菌、抗炎和抗肿瘤等活性。Talaromycessp.属广泛应用于食品和农业的生产,并在害虫的生物防治中也具有重要作用。因此,Talaromyces sp.属在医药、食品和农业等方面具有重要的研究价值和应用潜力。本文共收录了338种篮状菌属的次级代谢产物,包括38种生物碱、116种酯类、47种异香豆素类、69种聚酮类、16种醌类和52种甾体类及萜类化合物,这些数据能够为以后Talaromycessp.属的研究提供一定的参考价值,为医学、农业和环境等方面做出贡献。The secondary metabolites of endophytic fungi have been the focus of natural product research in recent years.Talaromyces sp.is an important endophytic fungus,a sexual species of Penicillium.Talaromyces sp.is widely distributed,and its secondary metabolites include alkaloids,peptides,esters,and polyketides,some of which have diverse biological activities,such as antibacterial,anti-inflammatory,and antitumor activities.Talaromyces sp.is widely used in food and agricultural production and also plays an important role in the biological control of pests.Therefore,Talaromyces sp.has important research value and application potential in medicine,food,and agriculture.In this paper,338 secondary metabolites of cyanobacterium were reviewed,including 38 alkaloids,116 esters,47 isocoumarins,69 polyketides,16 quinones,52 steroids,and terpenoids.The data in this paper could provide some reference value for future research on Talaromyces sp.and its contributions to medicine,agriculture,and the environment.

关 键 词：篮状菌属 次级代谢产物 化学结构 生物活性 

分 类 号：R932[医药卫生—生药学]