磁性聚合物胶束的制备及其药物释放行为研究  

Preparation of magnetic polymer micelles and their drug release behavior

作　　者：白飞 刘镔滨 张玮 农政将 郭坤 BAI Fei;LIU Bin-bin;ZHANG Wei;NONG Zheng-jiang;GUO Kun(School of Pharmacy,Southwest Minzu University,Chengdu 610225,China;Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau,Chengdu 610225,China)

机构地区：[1]西南民族大学药学院,四川成都610225 [2]四川省教育厅青藏高原民族药炮制制剂研究与应用实验室,四川成都610225

出　　处：《西南民族大学学报（自然科学版）》2024年第5期508-515,共8页Journal of Southwest Minzu University(Natural Science Edition)

基　　金：中国博士后科学基金面上项目(2020M673214);西南民族大学创新创业训练计划项目(项目编号:S202310656127);西南民族大学中央高校基本科研业务费专项资金项目(ZYN2024036)。

摘　　要：癌症是目前世界上最具致命性的疾病之一.为解决疏水性药物在体内无法维持长时间循环、代谢速度较快、生物利用率低的问题,通过β-环糊精(β-CD)与二茂铁(Fc)的主客体识别,采用制备主体分子β-CD覆盖的磁性纳米颗粒(CD-MNPs)和客体分子二茂铁修饰的聚乙二醇单甲醚(mPEG-Fc)以及二茂铁修饰的聚异丙基丙烯酰胺(PNIPAM-Fc),在磁性纳米颗粒表面构建了两种不同亲水性的聚合物链,在水中共组装形成直径约250 nm的规则球形胶束.通过改变温度,可以实现组装体系的形成与解体.研究结果表明,该胶束作为载体负载抗癌药物阿霉素(DOX),实现包封率73%,药物载量17%,并具有良好的缓释效果.所制备的磁性聚合物胶束具有良好稳定性以及较高的药物包封率和药物载量,在药物递送系统和可控释放领域具有潜在的应用前景.Cancer,a notoriously incurable disease,is primarily treated through chemotherapy,radiotherapy,and surgery.Chemotherapy often employs hydrophobic small-molecule drugs,which exhibit limited circulation in body fluids and rapid metabolism,potentially compromising therapeutic efficacy.To overcome these challenges,magnetic nanoparticles(NPs)coated withβ-CD(CD-MNPs)and ferrocene-modified polymers(mPEG-Fc and PNIPAM-Fc)were developed.Utilizing the host-guest recognition betweenβ-CD and ferrocene,polymer chains were constructed with varying hydrophobicity on the surface of the magnetic NPs.By adjusting temperature,the particle surface exhibited amphiphilic properties,self-assembling into spherical micelles with a diameter of approximately 250 nm.This assembly system could be reversibly formed and disintegrated by temperature modulation.Notably,when loaded with the anticancer drug DOX,these micelles exhibited an encapsulation rate of 73%and a drug loading capacity of 13%,demonstrating a favorable sustained release profile.The results suggested that this magnetic polymer micelle,exhibiting excellent stability,high drug encapsulation,and loading capacities,held promising potential for application in drug delivery and release systems.

关 键 词：超分子识别 自组装 磁性聚合物胶束 阿霉素 控释 

分 类 号：R943[医药卫生—药剂学] R96[医药卫生—药学] TB383[一般工业技术—材料科学与工程]