TcPO_(2)changes are more pronounced than SpO_(2)changes during simulated altitude changes in a hypobaric oxygen chamber:a nonrandomized controlled trial  

作　　者：Yang Li Liang Chen Ziyu Fu Zhiwei Wang Shijun Sun Xiaorong Luan Dedong Ma Tianliang Hu 

机构地区：[1]School of Nursing and Rehabilitation,Shandong University,Jinan,Shandong,China [2]Department of Emergency and Critical Care Medicine,Qilu Hospital of Shandong University,Jinan,Shandong,China [3]Department of Pulmonary and Critical Care Medicine,Qilu Hospital of Shandong University,Jinan,Shandong,China [4]Emergency Management Center of State Grid Shandong Electric Power Company,Jinan,Shandong,China [5]School of Nursing and Rehabilitation,Cheeloo College of Medicine,University of Shandong,Department of Infection Control,Qilu Hospital of Shandong University,Jinan,Shandong,China [6]School of Mechanical Engineering,Shandong University,Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing,National Experimental Teaching Demonstration Center for Mechanical Engineering,Jinan,Shandong,China

出　　处：《Emergency and Critical Care Medicine》2024年第3期105-110,共6页急危重症医学（英文）

基　　金：supported by grants from Shandong Province Key R&D Program(2021CXGC011301).

摘　　要：Background:Hypoxia is a significant risk factor of hypertension.However,no studies have used transcutaneous tissue partial pressure of oxygen(TcPO_(2))and partial pressure of carbon dioxide(TcPCO_(2))monitors to measure the respective partial pressures in healthy individuals.Oxygen saturation(SpO_(2))is often used for traditional monitoring of vital signs.This study investigated the changes in TcPO_(2)and SpO_(2)values during rapid changes in altitude.The trial was registered at ClinicalTrials.gov(registration no.NCT06076057).Methods:Healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber,which ascended from 0 m to 2500 m at a uniform speed within 10 min.The Danish Radiometer TCM4 was used to measure TcPO_(2)and TcPCO_(2)with the ventral side of the upper arm as the measurement site.The Shenzhen Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO_(2),with values recorded once every 500 m.Results:Altogether,49 healthy volunteers were recruited between March 2023 and August 2023.With increasing altitude,TcPO_(2)and SpO_(2)decreased significantly(P<0.01).During the ascent from 0 m,TcPO_(2)began to change statistically at 500 m(P<0.05),whereas SpO_(2)began to change statistically at 1000 m(P<0.05).At the same altitude,the difference in TcPO_(2)was greater than the difference in SpO_(2).At 1000 m,there were statistically significant changes in TcPO_(2)and SpO_(2)(P<0.001).At altitudes>500 m,statistical significance was identified between TcPO_(2)in both sexes(P<0.05).Statistical significance in TcPCO_(2)and heart rate was observed at the different elevations(P<0.05).Conclusion:In acutely changing low-pressure hypoxic environments,TcPO_(2)changed more dramatically than SpO_(2).

关 键 词：Altitude change Low-pressure oxygen chamber Transcutaneous oxygen saturation Transcutaneous partial pressure of oxygen 

分 类 号：R544[医药卫生—心血管疾病]