Serum amylase as a novel prognostic marker of organophosphorus poisoning:a retrospective study  

作　　者：Xinxin Guo Zhongwei Chen Ke Feng Siyao Zeng Junfei Zhang Zhe Ma Changda Yuan 

机构地区：[1]School of Clinical Medicine,Ningxia Medical University,Yinchuan,Ningxia Hui Autonomous Region,China [2]Emergency Department,General Hospital of Ningxia Medical University,Yinchuan,Ningxia Hui Autonomous Region,China

出　　处：《Emergency and Critical Care Medicine》2024年第3期111-116,共6页急危重症医学（英文）

基　　金：Ningxia Medical University General Hospital’s Ethics Committee(Ethics Number:KYLL-2022-1243).

摘　　要：Background:This study aims to explore the significance of serum amylase levels in patients with organophosphorus pesticide(OP)poisoning and to provide a new perspective for evaluating the severity and prognosis of OP poisoning.Methods:The clinical data of 67 patients with acute OP poisoning,who had been treated in the emergency department of the General Hospital of Ningxia Medical University between September 2020 and August 2022,were retrospectively analyzed.Using Spearman rank correlation,serum amylase levels during admission and severity of poisoning correlated with discharge outcomes.Based on serum amylase levels,receiver operating characteristic curves were plotted to predict the severity and mortality of patients who experience organophosphate poisoning.The optimal threshold serum amylase level at admission was determined based on the maximum Youden index.Results:Using Spearman rank correlation analysis,serum amylase levels at admission positively correlated with the severity of poisoning and discharge outcomes,but the degree of correlation was weak(r_(s):0.344;0.264;P<0.05).The patients’serum amylase levels at admission had receiver operating characteristic area under the curve values of 0.726 and 0.735 to predict the degree of severe poisoning and death,respectively.Based on the maximum Youden index,the optimal threshold of serum amylase were 97.8 and 194.1 U/L when the degree of poisoning was severe and the discharge outcome of patients was died.In comparison to patients with serum amylase levels≤194.1 U/L at admission,the OR values of death in patients with serum amylase levels>194.1 U/L at admission was 15.944(95%CI:1.825-139.274).Conclusion:Serum amylase levels in patients with organophosphate poisoning correlate with the degree of poisoning and discharge outcomes.Higher serum amylase level was a risk factor for organophosphorus poisoning death.

关 键 词：AMYLASE Emergency department Organophosphorus pesticide poisoning PROGNOSIS 

分 类 号：R459.7[医药卫生—急诊医学]