DP化疗方案联合康莱特注射液对肺腺癌患者免疫功能及血管新生指标的影响  

Effects of DP chemotherapy regimen combined with Kanglaite injection on immune function and angiogenesis indexes in patients with lung adenocarcinoma

作　　者：陈秀梅 黄海福 CHEN Xiumei;HUANG Haifu(Department of Oncology,Shenzhen Hospital(Futian),Guangzhou University of Traditional Chinese Medicine,Shenzhen 518000,China)

机构地区：[1]广州中医药大学深圳医院(福田)肿瘤科,深圳518000

出　　处：《上海医药》2024年第17期36-39,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨肺腺癌患者采用多西他赛^(+)顺铂(DP)化疗方案联合康莱特注射液治疗的效果。方法:将92例肺腺癌患者随机分为对照组和观察组,各46例。对照组实施DP化疗,观察组在此基础上加用康莱特注射液治疗,均治疗2个周期,比较两组治疗效果、免疫功能、血管新生指标及不良反应。结果:治疗后,观察组疾病控制率,CD3^(+)、CD4^(+)比例和CD4^(+)/CD8^(+)比值高于对照组;CD8^(+)比例,血管内皮生长因子A、碱性成纤维细胞生长因子水平和不良反应发生率低于对照组(P<0.05)。结论:DP化疗方案联合康莱特注射液治疗肺腺癌效果满意,可调节免疫功能及血管新生指标,且安全性好。Objective:To investigate the effect of docetaxel plus cisplatin(DP)chemotherapy regimen combined with Kanglaite injection in the treatment of patients with lung adenocarcinoma.Methods:Ninety-two patients with lung adenocarcinoma were randomly divided into a control group and an observation group with 46 cases each.The control group was treated with DP chemotherapy,while the observation group was additionally treated with Kanglaite injection,and all the treatments were lasted for two cycles.The treatment effect,immune function,angiogenesis indexes and incidence of adverse reactions were compared between the two groups.Results:After treatment,the disease control rate,CD3^(+),^(+)CD4 levels,CD4^(+)/CD8^(+)value were higher and the levels of CD8^(+),vascular endothelial growth factor A,basic fibroblast growth factor and the incidence of adverse reactions were lower in the observation group than the control group(P<0.05).Conclusion:DP chemotherapy regimen combined with Kanglaite injection for the treatment of lung adenocarcinoma is satisfactory and can regulate the immune function and angiogenesis indexes and has good safety.

关 键 词：肺腺癌 DP化疗方案 免疫功能 血管新生指标 不良反应 

分 类 号：R286[医药卫生—中药学] R734.2[医药卫生—中医学]