机械通气不同脱机方式对重症心力衰竭患者LEVF及血清BNP水平的影响  

The effect of different offline modes of mechanical ventilation on LEVF and serum BNP levels in patients with severe heart failure

作　　者：姚进超 郭凯 崔清涛 Yao Jinchao;Guo Kai;Cui Qingtao(Department of Critical Care Medicine,Liaocheng Maternal and Child Health Hospital,Liaocheng Shandong,252000,China)

机构地区：[1]聊城市妇幼保健院重症医学科,山东聊城252000

出　　处：《中外女性健康研究》2024年第10期21-24,共4页Women＇s Health Research

摘　　要：目的:探讨与分析机械通气不同脱机方式对重症心力衰竭(heart failure,HF)患者左室射血分数(LVEF)及血清B型钠尿肽(BNP)水平的影响。方法:2020年4月至2023年2月选择在本院诊治的重症心力衰竭92例作为研究对象,根据1∶1随机数字表法把92例患者分为研究组46例与对照组46例。所有患者都给予机械通气治疗,对照组给予常规方式脱机,研究组给予早期有创-无创序贯脱机处理,观察与记录患者LVEF及血清BNP水平变化情况。结果:治疗72h后研究组的总有效率为97.83%,对照组为84.78%,研究组与对照组相比显著提高(P<0.05)。两组治疗72h后的左室射血分数都高于治疗前(P<0.05),研究组治疗72h后的左室射血分数与对照组相比也显著提高(P<0.05)。两组治疗72h后的血清B型钠尿肽含量低于治疗前(P<0.05),研究组治疗72h后的血清B型钠尿肽含量与对照组相比也显著降低(P<0.05)。研究组脱机24h、脱机48h与脱机72h的成功率分别为97.83%、95.65%、91.30%,与对照组的82.61%、73.91%、60.87%相比有明显提高(P<0.05)。结论:早期有创-无创序贯脱机处理在重症心力衰竭患者的应用能提高总体治疗效果与左室射血分数,抑制血清B型钠尿肽的表达,从而提高对患者的脱机成功率。Objective:To explore and analysis the effects of different weaning methods of mechanical ventilation on left ventricular ejection fraction(LVEF)and serum B-type natriuretic peptide(BNP)levels in patients with severe heart failure(HF).Methods:From April 2020 to February 2023,92 cases of patients with severe heart failure who were diagnosed and treated at our hospital were selected as the research subjects.Accorded to a 1∶1 random number table method,92 patients were divided into the study group of 46 cases and the control group of 46 cases.All patients were received mechanical ventilation treatment,while routine offline were performed to control group.The study group were received early invasive non-invasive sequential offline treatment,and the changes in LVEF and serum B-type natriuretic peptide levels were observed and recorded.Results:After 72h of treatment,the total effective rate was 97.83%in the study group and 84.78%in the control group,which was significantly improved compared with the control group(P<0.05).The left ventricular ejection fraction after 72h of treatment in both groups was higher than that before treatment(P<0.05),and the left ventricular ejection fraction in the study group was significantly higher than that in the control group after 72h of treatment(P<0.05).The serum B type natriuretic peptide content of the two groups after 72h treatment was lower than that before treatment(P<0.05),and the serum B type natriuretic peptide content of the study group after 72h treatment was also significantly lower than that of the control group(P<0.05).The success rates of the study group were 97.83%,95.65%and 91.30%offline for 24h,48h and 72h,respectively,which were significantly higher than those of the control group(82.61%,73.91%and 60.87%,P<0.05).Conclusion:The application of early invasive non-invasive sequential weaning in patients with severe heart failure can improve overall treatment efficacy and left ventricular ejection fraction,inhibit the expression of serum B-type natriuretic peptide,and th

关 键 词：有创-无创序贯脱机 重症心力衰竭 左室射血分数 B型钠尿肽 机械通气 

分 类 号：R541.6[医药卫生—心血管疾病]