凝血功能、纤溶指标在妊娠高血压中的表达及联合用药后的变化分析  

Analysis of the diagnostic value of coagulation function and fibrinolysis indexes in pregnancy-induced hypertension

作　　者：单士超 Shan Shichao(Chengwu County People's Hospital of Shandong Province,Heze Shandong,274200,China)

机构地区：[1]山东省成武县人民医院,山东菏泽274200

出　　处：《中外女性健康研究》2024年第10期86-89,共4页Women＇s Health Research

摘　　要：目的:分析凝血功能、纤溶指标在妊娠高血压中的表达及给予联合用药后的变化。方法:选择本院2021年8月至2022年8月收治的妊娠期高血压患者84例为观察组,在同一时期选择于本院就诊的健康孕妇84例为对照组,检测并对比观察组及对照组的凝血功能、纤溶指标,之后根据患者高血压严重程度将观察组划分为轻度高血压(n=28)、中度高血压(n=28)以及子痫前期(n=28),对比不同高血压严重程度患者的凝血功能以及纤溶指标,最后给予观察组药物治疗,对比联合用药前、后观察组患者凝血功能、纤溶指标变化情况,借助受试者工作(receiver operating characteristic,ROC)曲线评估诊断效能。结果:两组受试者凝血功能、纤溶指标对比差异有统计学意义(P<0.05)。与治疗前相比,治疗后三组高血压患者的凝血功能、纤溶指标均有所下降,三组高血压患者凝血功能以及纤溶指标对比差异有统计学意义(P<0.05)。ROC曲线分析结果显示,PT的曲线下面积(area under curve,AUC)为1.000,其灵敏度以及特异度分别为100.00%、100.00%,高于其他指标检测的水平。结论:凝血、纤溶指标与妊娠期高血压发病之间存在密切关系,能够为早期妊娠期高血压患者的诊断、治疗提供数据参考,并在治疗后期起到评估预后的作用。Objective:To analyze the expression of coagulation function and fibrinolysis index in pregnancy-induced hypertension and their changes after combined administration.Methods:84 patients with gestational hypertension admitted to our hospital from August 2021 to August 2022 were selected as the observation group,and 84 healthy pregnant women who visited our hospital during the same period were selected as the control group.The coagulation function and fibrinolytic indicators of the observation group and the control group were tested and compared.Then,based on the severity of hypertension in the patients,the observation group was divided into mild hypertension(n=28),moderate hypertension(n=28),and preeclampsia(n=28),compare the coagulation function and fibrinolytic indicators of patients with different severity of hypertension,and finally give medication treatment to the observation group.Compare the changes in coagulation function and fibrinolytic indicators of patients in the observation group before and after the combination of medication,and evaluate the diagnostic efficacy using the receiver operating characteristic(ROC)curve.Results:There was a statistically significant difference in coagulation function and fibrinolysis indicators between the two groups of subjects(P<0.05).Compared with before treatment,the coagulation function and fibrinolytic indicators of the three groups of hypertensive patients decreased after treatment,and there was a statistically significant difference in coagulation function and fibrinolytic indicators among the three groups of hypertensive patients(P<0.05).The ROC curve analysis results show that the area under curve(AUC)of PT is 1.000,and its sensitivity and specificity are 100.00%and 100.00%,respectively,which are higher than the levels detected by other indicators.Conclusion:There is a close relationship between coagulation and fibrinolysis indexes and the incidence of pregnancy-induced hypertension,which can provide data reference for the diagnosis and treatment of early pregnanc

关 键 词：妊娠高血压 凝血功能 纤溶指标 药物治疗 

分 类 号：R714.25[医药卫生—妇产科学]