瑞马唑仑联合瑞芬太尼对膀胱镜碎石手术麻醉效果及血流动力学影响  

Effect of remazolam combined with remifentanil on anesthesia and hemodynamics of cystoscopic lithotripsy

作　　者：吴冬金[1] 杨雅婷 刘洋[1] WU Dong-Jin;YANG Ya-Ting;LIU Yang(Department of Anesthesiology,The First Affiliated Hospital of Xiamen University,Fujian 361003,Xiamen,China)

机构地区：[1]厦门大学附属第一医院麻醉科,福建厦门361003

出　　处：《吉林医学》2024年第10期2450-2453,共4页Jilin Medical Journal

基　　金：福建省自然科学基金资助项目[项目编号:2020J01094]。

摘　　要：目的:探讨瑞马唑仑联合瑞芬太尼对膀胱镜碎石手术麻醉效果及血流动力学影响。方法:选取厦门大学附属第一医院2023年1月~2024年2月需要住院行膀胱镜碎石手术的82例患者为研究对象,根据随机数字表法分为瑞马唑仑组(R组,n=41)和丙泊酚组(P组,n=41),R组使用瑞马唑仑联合瑞芬太尼进行麻醉,P组使用丙泊酚联合瑞芬太尼进行麻醉。比较两组麻醉起效时间、麻醉苏醒时间、拔管时间。比较两组患者在麻醉诱导前(T0)、麻醉给药后(T1)、置入喉罩后(T2)和拔除喉罩后(T3)时刻的血流动力学变化。评估围术期麻醉相关不良事件发生情况。结果:与P组相比,R组起效时间较慢,R组苏醒时间以及拔管时间更短,差异具有统计学意义(P<0.05)。R组和P组T1时间、T2时间、T3时间的平均动脉压(MAP),差异均具有统计学意义(P<0.05)。R组和P组T1时间,差异具有统计学意义(P<0.05)。R组注射痛、低血压、心动过缓的不良反应明显低于P组,差异有统计学意义(P<0.05)。其余不良反应差异无统计学意义(P>0.05)。结论:瑞马唑仑联合瑞芬太尼在膀胱镜碎石手术中具有良好的麻醉效果,对血流动力学影响较小,能够有效维持血流动力学稳定。Objective To investigate the effect of remazolam combined with remifentanil on anesthesia and hemodynamics of cystoscopic lithotripsy.Method 82 patients who needed to be hospitalized for cystoscopic lithotripsy at the First Affiliated Hospital of Xiamen University from January 2023 to February 2024 were selected as the study subjects.They were randomly divided into two groups using a random number table:the remimazolam group(R group,n=41)and the propofol group(P group,n=41).The R group received anesthesia with remimazolam combined with remifentanil,while the P group received anesthesia with propofol combined with remifentanil.Compare the onset time,awakening time,and extubation time of anesthesia between two groups of patients.Compare the hemodynamic changes of two groups of patients before anesthesia induction(T0),after anesthesia administration(T1),after placement of laryngeal mask(T2),and after removal of laryngeal mask(T3).Assess the incidence of adverse events related to perioperative anesthesia.Results Compared with the propofol group P,the remimazolam group R had a slower onset time,a shorter awakening time and a shorter extubation time,with statistically significant differences(P<0.05).There was a statistically significant difference in the MAP of T1,T2,T3 time for R group and P group(P<0.05).There was a statistically significant difference in the HR of T1 time between R group and P group(P<0.05).The adverse reactions of injection pain,hypotension,and bradycardia in Group R were significantly lower than those in Group P,and the difference was statistically significant(P<0.05).There was no statistically significant difference in other adverse reactions(P>0.05).Conclusion Remazolam combined with remifentanil in cystoscopic lithotripsy has a good anesthetic effect,and has little influence on the hemodynamics,and can effectively maintain the hemodynamic stability.

关 键 词：瑞马唑仑 瑞芬太尼 膀胱镜碎石手术 麻醉效果 血流动力学 

分 类 号：R971.2[医药卫生—药品]