妊娠合并慢性乙型肝炎患者乙肝标志物、前S1抗原与HBV-DNA的关系研究  

Study on the relationship between hepatitis B markers, Pre-S1 antigen and HBV-DNA in pregnant patients with chronic hepatitis B

作　　者：董媛媛 李磊 李昭 虎文祥 马莉[1] DONG Yuanyuan;LI Lei;LI Zhao;HU Wenxiang;MA Li(Laboratory Department,Beijing Road Medical District,General Hospital of Xinjiang Military Region/Xinjiang 474 Hospital,Urumqi 830000,China)

机构地区：[1]新疆军区总医院北京路医疗区/新疆四七四医院检验科,新疆乌鲁木齐830000

出　　处：《临床医学研究与实践》2024年第28期27-30,共4页Clinical Research and Practice

基　　金：新疆军区总医院北京路医疗区重点扶持科研项目(No.2022jzbjI11)。

摘　　要：目的 研究妊娠合并慢性乙型肝炎(CHB)患者乙肝标志物、前S1抗原(Pre-S1Ag)与乙型肝炎病毒核酸(HBV-DNA)的关系。方法 选取2022年5月至2023年12月我院收治的100例妊娠合并CHB患者为研究对象,依据HBV-DNA定量测定结果将其分为阳性组与阴性组,每组50例。比较两组的乙肝标志物、Pre-S1Ag水平、肝功能指标及不良妊娠结局;分析妊娠合并CHB患者乙肝标志物、Pre-S1Ag以及各项肝功能指标与HBV-DNA的相关性。结果 阳性组的乙型肝炎表面抗原(HBsAg)、乙型肝炎e抗原(HBe Ag)、Pre-S1Ag水平均高于阴性组,乙型肝炎表面抗体(HBsAb)、乙型肝炎e抗体(HBeAb)、乙型肝炎核心抗体(HBcAb)水平低于阴性组(P<0.05)。阳性组的各项肝功能指标水平均高于阴性组(P<0.05)。阳性组的剖宫产、胎膜早破、产后出血及羊水粪染发生率均高于阴性组(P<0.05)。Pearson相关性分析结果显示,妊娠合并CHB患者HBsAg、HBe Ag、Pre-S1Ag及各项肝功能指标均与HBV-DNA呈正相关,HBsAb、HBeAb及HBcAb与HBV-DNA呈负相关(P<0.05)。结论 妊娠合并CHB患者的乙肝标志物、Pre-S1Ag以及肝功能指标均与HBV-DNA密切相关。Objective To study the relationship between hepatitis B markers,Pre-S1 antigen(Pre-S1Ag)and hepatitis B virus-DNA(HBV-DNA)in pregnant women with chronic hepatitis B(CHB).Methods A total of 100 pregnant patients with CHB admitted in our Hospital from May 2022 to December 2023 were selected as the study objects.According to the results of HBV-DNA quantitave determination,the patients were divided into positive group and negative group,with 50 cases in each group.The hepatitis B markers,Pre-S1Ag levels,liver function indexes and adverse pregnancy outcomes were compared between the two groups;the correlation between hepatitis B markers,Pre-S1Ag,liver function indexes and HBV-DNA in pregnant patients with CHB were analyzed.Results The levels of hepatitis B surface antigen(HBsAg),hepatitis B e antigen(HBeAg)and Pre-S1Ag in the positive group were higher than those in the negative group,and the levels of hepatitis B surface antibody(HBsAb),hepatitis B e antibody(HBeAb)and hepatitis B core antibody(HBcAb)were lower than those in the negative group(P<0.05).The levels of liver function indexes in the positive group were higher than those in the negative group(P<0.05).The incidences of cesarean section,premature rupture of membranes,postpartum hemorrhage and amniotic fluid fecal staining in the positive group were higher than those in the negative group(P<0.05).Pearson correlation analysis results showed that HBsAg,HBeAg,Pre-S1Ag and liver function indexes of pregnant patients with CHB were positively correlated with HBV-DNA,while HBsAb,HBeAb and HBcAb were negatively correlated with HBV-DNA(P<0.05).Conclusion HBV-DNA is closely related to hepatitis B markers,Pre-S1Ag and liver function indexes in pregnant patients with CHB.

关 键 词：妊娠 慢性乙型肝炎 乙肝标志物 前S1抗原 乙型肝炎病毒核酸 

分 类 号：R512.62[医药卫生—内科学]